BRD32048
- Product Name
- BRD32048
- CAS No.
- 433694-46-3
- Chemical Name
- BRD32048
- Synonyms
- BRD32048;N2-(4-Methoxyphenyl)-6-(piperidin-1-ylmethyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, N2-(4-methoxyphenyl)-6-(1-piperidinylmethyl)-;ETV1 direct binder,DNA/RNA Synthesis,ETV1 perturbagen,transcription factor,acetylation,Inhibitor,BRD32048,degradation,inhibit
- CBNumber
- CB83067538
- Molecular Formula
- C16H22N6O
- Formula Weight
- 314.39
- MOL File
- 433694-46-3.mol
BRD32048 Property
- Boiling point:
- 545.3±60.0 °C(Predicted)
- Density
- 1.268±0.06 g/cm3(Predicted)
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml
- form
- A crystalline solid
- pka
- 7.87±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 16516
- Product name
- BRD32048
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 16516
- Product name
- BRD32048
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $43
- Updated
- 2023/06/20
- Product number
- 16516
- Product name
- BRD32048
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- 2236CD
- Product name
- N2-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine
- Packaging
- 1mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 2236CD
- Product name
- N2-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine
- Packaging
- 5mg
- Price
- $478
- Updated
- 2021/12/16
BRD32048 Chemical Properties,Usage,Production
Description
ETS variant 1 (ETV1) is a transcription factor oncogene implicated in several cancers where it has been altered by chromosomal translocation, gene amplification, or lineage dysregulation. The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300. Both of these events increase the protein half-life of ETV1 and enhance its transcriptional activity. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 (KD = 17.1 μM in vitro), which reduces p300-dependent acetylation and stability of ETV1 and, thereby, promotes its degradation. At 20-100 μM, BRD32048 can dose-dependently prevent invasion of ETV1-reliant cancer cells in in vitro models.
Definition
ChEBI: N2-(4-methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine is a member of methoxybenzenes and a substituted aniline.
BRD32048 Preparation Products And Raw materials
Raw materials
Preparation Products
BRD32048 Suppliers
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