ChemicalBook > CAS DataBase List > Cuspin-1

Cuspin-1

Product Name
Cuspin-1
CAS No.
337932-29-3
Chemical Name
Cuspin-1
Synonyms
Cuspin-1;Cuspin 1,Cuspin1;Cuspin-1 >=98% (HPLC);(5-Bromo-3-pyridinyl)(4-methylphenyl)methanone;Methanone, (5-bromo-3-pyridinyl)(4-methylphenyl)-
CBNumber
CB83067543
Molecular Formula
C13H10BrNO
Formula Weight
276.1286
MOL File
337932-29-3.mol
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Cuspin-1 Property

storage temp. 
Store at -20°C
solubility 
DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 16 mg/mL; Ethanol: 1 mg/mL
form 
A crystalline solid
color 
brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
18526
Product name
Cuspin-1
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
18526
Product name
Cuspin-1
Purity
≥98%
Packaging
10mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
18526
Product name
Cuspin-1
Purity
≥98%
Packaging
25mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
18526
Product name
Cuspin-1
Purity
≥98%
Packaging
50mg
Price
$384
Updated
2024/03/01
TRC
Product number
C845005
Product name
Cuspin1
Packaging
10mg
Price
$85
Updated
2021/12/16
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Cuspin-1 Chemical Properties,Usage,Production

Description

The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.

Uses

Cuspin 1 is used in cuspin-1 characterization and regulation of SMN protein via Ras signaling in spinal muscular atropy.

References

[1] REKA R. LETSO. Small Molecule Screen Reveals Regulation of Survival Motor Neuron Protein Abundance by Ras Proteins[J]. ACS Chemical Biology, 2013, 8 5: 914-922. DOI: 10.1021/cb300374h

Cuspin-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Cuspin-1 Suppliers

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337932-29-3, Cuspin-1Related Search:


  • Cuspin-1
  • Methanone, (5-bromo-3-pyridinyl)(4-methylphenyl)-
  • Cuspin-1 >=98% (HPLC)
  • Cuspin 1,Cuspin1
  • (5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
  • 337932-29-3