Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate
- Product Name
- Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate
- CAS No.
- 188528-95-2
- Chemical Name
- Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate
- Synonyms
- Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate;1-tert-Butyl 3-ethyl 2-oxopyrrolidine-1,3-dicarboxylate;O1-tert-butyl O3-ethyl 2-oxopyrrolidine-1,3-dicarboxylate;1-O-Tert-Butyl 3-O-Ethyl 2-Oxopyrrolidine-1,3-Dicarboxylate;1-tert-butyl 2-oxopyrrolidine-1,3-dicarboxylate 3-ethyl ester;2-oxopyrrolidin-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester;1,3-Pyrrolidinedicarboxylic acid, 2-oxo-, 1-(1,1-dimethylethyl) 3-ethylester;2-oxopyrrolidin-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester, 1-tert-butyl 2-oxopyrrolidine-1,3-dicarboxylate 3-ethyl ester
- CBNumber
- CB83070860
- Molecular Formula
- C12H19NO5
- Formula Weight
- 257.28
- MOL File
- 188528-95-2.mol
Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate Property
- Boiling point:
- 375.0±35.0 °C(Predicted)
- Density
- 1.182±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.26±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
N-Bromosuccinimide Price
- Product number
- CS-0038884
- Product name
- 1-(tert-Butyl)3-ethyl2-oxopyrrolidine-1,3-dicarboxylate
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0038884
- Product name
- 1-(tert-Butyl)3-ethyl2-oxopyrrolidine-1,3-dicarboxylate
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $245
- Updated
- 2021/12/16
- Product number
- CS-0038884
- Product name
- 1-(tert-Butyl)3-ethyl2-oxopyrrolidine-1,3-dicarboxylate
- Purity
- ≥98.0%
- Packaging
- 10g
- Price
- $440
- Updated
- 2021/12/16
- Product number
- CM250752
- Product name
- 1-tert-Butyl3-ethyl2-oxopyrrolidine-1,3-dicarboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $757
- Updated
- 2021/12/16
- Product number
- CD21011895
- Product name
- 1-tert-Butyl3-ethyl2-oxopyrrolidine-1,3-dicarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $802
- Updated
- 2021/12/16
Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate Chemical Properties,Usage,Production
Synthesis
541-41-3
188528-95-2
A THF solution (10 mL) of tert-butyl 2-oxopyrrolidine-1-carboxylate (500 mg, 2.70 mmol) was slowly added dropwise to a THF solution (5.4 mL, 5.4 mmol) of 1M lithium hexamethyldisilazane at -78 °C and the reaction mixture was stirred for 50 min at this temperature. Subsequently, a THF solution (5 mL) of ethyl chloroformate (0.27 mL, 2.84 mmol) was added dropwise to the above reaction solution at -78 °C. The reaction system was gradually warmed up to room temperature and stirring was continued for 4 hours. Upon completion of the reaction, the reaction solution was poured into saturated aqueous ammonium chloride solution and extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent ratio: hexane/ethyl acetate=5:1 to 2:1) to afford 1-tert-butyl 3-ethyl 2-oxopyrrolidine-1,3-dicarboxylate (468 mg, 67% yield) as a liver-brown oily substance.1H-NMR (270 MHz, CDCl3) δ (ppm): 1.31 (3H, t, J=7.1 Hz) , 1.53 (9H, s), 2.16-2.46 (2H, m), 3.53 (1H, dd, J=7.4, 9.1 Hz), 3.66-3.75 (1H, m), 3.84-3.93 (1H, m), 4.24 (2H, dd, J=7.1, 14.3 Hz).ESI (LC-MS positive mode) m/z 258 (M +H).
References
[1] Patent: EP1854792, 2007, A1. Location in patent: Page/Page column 108
Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 1-Boc-2-Oxopyrrolidine-3-Carboxylate manufacturers
- Product
- 2-oxopyrrolidin-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 188528-95-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 100kg; 1000kg
- Release date
- 2019-12-24