PF-04929113 (Mesylate)
- Product Name
- PF-04929113 (Mesylate)
- CAS No.
- 1173111-67-5
- Chemical Name
- PF-04929113 (Mesylate)
- Synonyms
- SNX5422 Mesylate;SNX-5422 Mesylate;PF-04929113 (Mesylate);PF-04929113 Mesylate, 10 mM in DMSO;SNX-5422 MESYLATE (PF-04929113 MESYLATE);PF 04929113 Mesylate,PF04929113 Mesylate;SNX-5422 MESYLATE;PF04929113 MESYLATE;SNX5422 MESYLATE;trans-4-((2-Carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate methanesulfonate;(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate methanesulfonate
- CBNumber
- CB83121124
- Molecular Formula
- C26H34F3N5O7S
- Formula Weight
- 617.64
- MOL File
- 1173111-67-5.mol
PF-04929113 (Mesylate) Property
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:46.85(Max Conc. mg/mL);75.85(Max Conc. mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P293785
- Product name
- PF-04929113(Mesylate)
- Packaging
- 10mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- orb611733
- Product name
- PF-04929113 Mesylate
- Packaging
- 10mg
- Price
- $460.7
- Updated
- 2021/12/16
- Product number
- orb611733
- Product name
- PF-04929113 Mesylate
- Packaging
- 50mg
- Price
- $734.4
- Updated
- 2021/12/16
- Product number
- 2765DF
- Product name
- SNX-5422mesylate
- Packaging
- 250mg
- Price
- $834
- Updated
- 2021/12/16
- Product number
- A202225
- Product name
- PF-04929113Mesylate
- Purity
- 98%
- Packaging
- 2mg
- Price
- $99
- Updated
- 2021/12/16
PF-04929113 (Mesylate) Chemical Properties,Usage,Production
Uses
PF-04929113 (Mesylate) functions as a potent and selective Hsp90 inhibitor. Substances in the discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
in vivo
SNX-5422 (50 mg/kg, p.o.) efficiently inhibits tumor growth of HT-29 human colon tumor xenograft model after administration 3 times a week for 3 weeks (qod × 3/2 × 3)[1]. SNX-5422 (20, 40 mg/kg, p.o.) markedly inhibits multiple myeloma (MM) tumor growth and angiogenesis in mice[2].
IC 50
HSP90: 41 nM (Kd)
PF-04929113 (Mesylate) Preparation Products And Raw materials
Raw materials
Preparation Products
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