SLx-4090
- Product Name
- SLx-4090
- CAS No.
- 913541-47-6
- Chemical Name
- SLx-4090
- Synonyms
- KD-026;SLx-4090;KD-026 913541-47-6;KD-026, 10 mM in DMSO;KD 026,microsomal triglyceride transfer protein,MTP inhibitor,inhibit,Inhibitor,enterocytic-specific,dyslipidemia;phenyl 6-(6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)-3,4-dihydroisoquinoline-2(1h)-carboxylate;Phenyl 6-(6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)-3,4-dihydroisoquinoline-2(1H)-carboxylate;2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-[[[6-methoxy-4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-, phenyl ester
- CBNumber
- CB83122040
- Molecular Formula
- C31H25F3N2O4
- Formula Weight
- 546.54
- MOL File
- 913541-47-6.mol
SLx-4090 Property
- storage temp.
- 4°C, protect from light
- solubility
- DMSO: Sparingly soluble: 1-10 mg/mL
Ethanol: Slightly soluble: 0.1-1 mg/mL - form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
SLx-4090 Chemical Properties,Usage,Production
Uses
SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia[1].
in vivo
SLX-4090 (orally, 30 mg/kg) reduces postprandial lipids by 50% with an ED50 value 7 mg/kg in rats[1].
References
[1] Enoch Kim, et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85. DOI:10.1124/jpet.110.177527
SLx-4090 Preparation Products And Raw materials
Raw materials
Preparation Products
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