ChemicalBook > CAS DataBase List > GAL-021

GAL-021

Product Name: GAL-021
CAS No.: 1380341-99-0
Chemical Name: GAL-021
Synonyms: GAL-021;GAL-021, >98%;GAL021;GAL 021;GAL-021, 1380341-99-0;GAL-021, 10 mM in DMSO;N2-methoxy-N2-methyl-N4,N6-dipropyl-1,3,5-triazine-2,4,6-triamine;6-(Methoxy(methyl)amino)-N2,N4-dipropyl-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4,6-triamine, N2-methoxy-N2-methyl-N4,N6-dipropyl-;KCa1.1,GAL-021,minute ventilation,inhibit,BKCa,Inhibitor,KcsA,breathing control modulator,GH3 cells,Potassium Channel,GAL021,almitrine pharmacophore
CBNumber: CB83126725
Molecular Formula: C11H22N6O
Formula Weight: 254.33
MOL File: 1380341-99-0.mol

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GAL-021 Property

Boiling point:: 390.6±25.0 °C(Predicted)
Density: 1.164±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 3 mg/ml; DMSO: 5 mg/ml; Ethanol: Slightly soluble; PBS (pH 7.2): 0.30 mg/ml
form: A crystalline solid
pka: 7.07±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22609
Product name: GAL-021
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 22609
Product name: GAL-021
Purity: ≥95%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 22609
Product name: GAL-021
Purity: ≥95%
Packaging: 10mg
Price: $278
Updated: 2024/03/01

Cayman Chemical

Product number: 22609
Product name: GAL-021
Purity: ≥95%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-6340
Product name: GAL-021
Purity: >98.0%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

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GAL-021 Chemical Properties,Usage,Production

Uses

GAL-021 is a potent BKCa-channel blocker. GAL-021 inhibits KCa1.1 in GH3 cells. GAL-021 is a novel breathing control modulator that is based on selective modification of the almitrine pharmacophore. GAL-021 increases minute ventilation in rats and non-human primates[1][2].

in vivo

Intravenously administered GAL-021 attenuates opiate-induced respiratory depression in rats and nonhuman primates without affecting analgesia in rats. GAL-021 ventilatory stimulation in rats is attenuated by carotid sinus nerve transection. GAL-021 ventilatory stimulation is attenuated in mice lacking the pore-forming α-subunit of the KCa 1.1 channel^[1].

References

[1] Golder FJ, et al. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Anesthesiology. 2015 Nov;123(5):1093-104. DOI:10.1097/ALN.0000000000000844
[2] J F McLeod, et al. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014 Nov;113(5):875-83. DOI:10.1093/bja/aeu182

GAL-021 Preparation Products And Raw materials

Raw materials

Preparation Products

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1380341-99-0, GAL-021Related Search:

GAL-021

GAL-021, 1380341-99-0

GAL021;GAL 021

GAL-021, >98%

1,3,5-Triazine-2,4,6-triamine, N2-methoxy-N2-methyl-N4,N6-dipropyl-

KCa1.1,GAL-021,minute ventilation,inhibit,BKCa,Inhibitor,KcsA,breathing control modulator,GH3 cells,Potassium Channel,GAL021,almitrine pharmacophore

6-(Methoxy(methyl)amino)-N2,N4-dipropyl-1,3,5-triazine-2,4-diamine

N2-methoxy-N2-methyl-N4,N6-dipropyl-1,3,5-triazine-2,4,6-triamine

GAL-021, 10 mM in DMSO

1380341-99-0