Decapeptide-12
- Product Name
- Decapeptide-12
- CAS No.
- 137665-91-9
- Chemical Name
- Decapeptide-12
- Synonyms
- Decapeptide-12;Decapeptide-12/ Lumixyl;Decapeptide-12 USP/EP/BP;Decapeptide-12 lumixyl / cosmetic peptide;H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH;L-Tyrosine, L-tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl-
- CBNumber
- CB83128840
- Molecular Formula
- C65H90N18O17
- Formula Weight
- 1395.52
- MOL File
- 137665-91-9.mol
Decapeptide-12 Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- pka
- 3.07±0.10(Predicted)
- Sequence
- H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH
- InChIKey
- OYVFAMLECFSFEI-XJHNTGDTSA-N
Decapeptide-12 Chemical Properties,Usage,Production
Description
Decapeptide-12 is an oligopeptide that is made up of just 10 amino acids. This oligopeptide is known for its anti-tyrosinase activity. Tyrosinase is accountable for producing melanin in the skin. Decapeptide 12 connects to tyrosinase and prevents it from catalyzing the oxidation of phenols – the initial step in melanin creation. It’s able to interfere with tyrosinase and lighten skin.
Uses
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].
References
[1] Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. DOI:10.1038/jid.2009.124
[2] Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. DOI:10.1016/j.jbiosc.2015.10.010
[3] Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39.
Decapeptide-12 Preparation Products And Raw materials
Raw materials
Preparation Products
Decapeptide-12 Suppliers
- Tel
- +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4802
- Advantage
- 58
- Tel
- 17711399154
- 3211919385@qq.com
- Country
- China
- ProdList
- 1815
- Advantage
- 58
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- 0551-65326643 18156095617
- Fax
- 0551-65326641
- info@cellmano.com
- Country
- China
- ProdList
- 1010
- Advantage
- 55
- Tel
- 0838-6510595 13402890778 15102836436
- 1120021438@qq.com
- Country
- China
- ProdList
- 132
- Advantage
- 56
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 0571-89197072; 18668118770
- Fax
- 0571-89197072
- linda@peptide-china.com
- Country
- China
- ProdList
- 235
- Advantage
- 56
- Tel
- 021-58088081 Q2635253576
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 2081
- Advantage
- 55
- Tel
- 0510-83583050 13771062561
- Fax
- 0510-83583039
- willsun@peptide-search.com
- Country
- China
- ProdList
- 6716
- Advantage
- 58
View Lastest Price from Decapeptide-12 manufacturers
- Product
- Decapeptide-12 137665-91-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-23
- Product
- Decapeptide-12 137665-91-9
- Price
- US $0.00-0.00/Box
- Min. Order
- 1Box
- Purity
- 99.99%
- Supply Ability
- 10 Boxes
- Release date
- 2025-06-10
- Product
- Decapeptide-12 137665-91-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.00009999999747378752kg
- Purity
- 99.99%
- Supply Ability
- 2000000T
- Release date
- 2025-06-10