Decapeptide-12
- Product Name
- Decapeptide-12
- CAS No.
- 137665-91-9
- Chemical Name
- Decapeptide-12
- Synonyms
- Decapeptide-12;Decapeptide-12/ Lumixyl;Decapeptide-12 USP/EP/BP;Decapeptide-12 lumixyl / cosmetic peptide;H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH;L-Tyrosine, L-tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl-
- CBNumber
- CB83128840
- Molecular Formula
- C65H90N18O17
- Formula Weight
- 1395.52
- MOL File
- 137665-91-9.mol
Decapeptide-12 Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- pka
- 3.07±0.10(Predicted)
- Sequence
- H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH
- Cosmetics Ingredients Functions
- SKIN CONDITIONING
BLEACHING - InChIKey
- OYVFAMLECFSFEI-XJHNTGDTSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
Decapeptide-12 Chemical Properties,Usage,Production
Description
Decapeptide-12 is an oligopeptide that is made up of just 10 amino acids. This oligopeptide is known for its anti-tyrosinase activity. Tyrosinase is accountable for producing melanin in the skin. Decapeptide 12 connects to tyrosinase and prevents it from catalyzing the oxidation of phenols – the initial step in melanin creation. It’s able to interfere with tyrosinase and lighten skin.
Uses
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3].
References
[1] Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. DOI:10.1038/jid.2009.124
[2] Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. DOI:10.1016/j.jbiosc.2015.10.010
[3] Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39.
Decapeptide-12 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Decapeptide-12 manufacturers
- Product
- Decapeptide-12 137665-91-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-23
- Product
- Decapeptide-12 137665-91-9
- Price
- US $0.00-0.00/Box
- Min. Order
- 1Box
- Purity
- 99.99%
- Supply Ability
- 10 Boxes
- Release date
- 2025-06-10
- Product
- Decapeptide-12 137665-91-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.00009999999747378752kg
- Purity
- 99.99%
- Supply Ability
- 2000000T
- Release date
- 2025-06-10