EFT-508

ChemicalBook > CAS DataBase List > EFT-508

Product Name: EFT-508
CAS No.: 1849590-01-7
Chemical Name: EFT-508
Synonyms: CS-2450;EFT-508;eFT508 -MNK;Tomivosertib;eFT-508 (eFT508);Tomivosertib eFT508;eFT508(Tomivosertib);EFT 508;EFT-508;TOMIVOSERTIB;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione;6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione
CBNumber: CB83133222
Molecular Formula: C17H20N6O2
Formula Weight: 340.38
MOL File: 1849590-01-7.mol

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EFT-508 Property

Melting point:: >300°C
Boiling point:: 735.6±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: DMSO (Slightly, Heated), Methanol (Very Slightly)
pka: 13.77±0.60(Predicted)
form: Solid
color: Pale Yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21957
Product name: eFT508
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 21957
Product name: eFT508
Purity: ≥98%
Packaging: 5mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 21957
Product name: eFT508
Purity: ≥98%
Packaging: 10mg
Price: $535
Updated: 2024/03/01

Cayman Chemical

Product number: 21957
Product name: eFT508
Purity: ≥98%
Packaging: 25mg
Price: $1002
Updated: 2024/03/01

TRC

Product number: A629153
Product name: 6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione
Packaging: 5mg
Price: $150
Updated: 2021/12/16

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EFT-508 Chemical Properties,Usage,Production

Description

eFT508 is a potent inhibitor of MAPK interacting protein kinases (MNK) 1 and 2 (IC₅₀s = <10 nM). It inhibits phosphorylation of eukaryotic initiation factor 4E (eIF4E) with an IC₅₀ value of <50 nM in a cellular signaling assay. eFT508 has a half-life of 5.3 hours in rats.

Uses

6''-[(6-Amino-4-pyrimidinyl)amino]-8''-methylspiro[cyclohexane-1,3''(2''H)-imidazo[1,5-a]pyridine]-1'',5''-dione was used in the study of inhibitors of immune checkpoint modulators and related methods. eFT508 is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor.

EFT-508 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from EFT-508 manufacturers

Career Henan Chemical Co

Product: EFT-508 1849590-01-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1849590-01-7, EFT-508Related Search:

2,4,6-Triaminopyrimidine

EFT-508

6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione

eFT508 -MNK

6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione

Tomivosertib

eFT-508 (eFT508)

Tomivosertib eFT508

CS-2450

EFT 508;EFT-508;TOMIVOSERTIB

6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione

Spiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione, 6'-[(6-amino-4-pyrimidinyl)amino]-8'-methyl-

eFT508(Tomivosertib)

6'-((6-Aminopyrimidin-4-yl)amino)-8'-methyl-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'(2'H)-dione

6'-[(6-aminopyrimidin-4-yl)amino]-8'-methyl-2',5'-dihydro-1'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione

6-[(6-aminopyrimidin-4-yl)amino]-8-methylspiro[2H-imidazo[1,5-a]pyridine-3,1'-cyclohexane]-1,5-dione

6'-[(6-Amino-4-pyrimidinyl)amino]-8'-methylspiro[cyclohexane-1,3'(2'H)-imidazo[1,5-a]pyridine]-1',5'-dione

1849590-01-7

849590-01-7