ACETAZOLAMIDE SODIUM

Product Name: ACETAZOLAMIDE SODIUM
CAS No.: 1424-27-7
Chemical Name: ACETAZOLAMIDE SODIUM
Synonyms: diamoxsodium;SODIUMACETAZOLAMIDE;ACETAZOLAMIDE SODIUM;acetazolamidesodiumsalt;n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt;n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt
CBNumber: CB8313562
Molecular Formula: C4H7N4NaO3S2
Formula Weight: 246.23
MOL File: 1424-27-7.mol

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ACETAZOLAMIDE SODIUM Property

storage temp.: 4°C, away from moisture
solubility: DMSO : 100 mg/mL (407.76 mM; Need ultrasonic)
form: Solid
color: Powder fine white

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Safety

Toxicity: ACETAZOLAMIDE SODIUM SALT ?? SODIUMACETAZOLAMIDE

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0008931
Product name: ACETAZOLAMIDE SODIUM
Purity: 95.00%
Packaging: 5MG
Price: $500.05
Updated: 2021/12/16

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ACETAZOLAMIDE SODIUM Chemical Properties,Usage,Production

Uses

Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].

Definition

ChEBI: Acetazolamide sodium is an organic sodium salt. It contains an acetazolamide and an acetazolamide(1-).

brand name

Diamox (Duramed).

Safety Profile

ACETAZOLAMIDE SODIUM SALT ?? SODIUMACETAZOLAMIDE

in vivo

Acetazolamide (40 mg/kg) significantly potentiates the inhibitory effect of MS-275 on tumorigenesis in neuroblastoma (NB) SH-SY5Y xenografts^[3].
? Acetazolamide (40 mg/kg) and/or MS-275 treatment reduce expression of HIF1-α and CAIX in NB SH-SY5Y xenograft^[3].
? Acetazolamide (40 mg/kg), MS-275 and Acetazolamide+MS-275 reduce expression of mitotic and proliferative markers in NB SH-SY5Y xenografts^[3].? Acetazolamide (50 mg/kg; PO, for 3 days) significantly reduces the gonococcal load in the vagina of infected mice by 90%^[6].

IC 50

CA Ⅸ

References

[1] Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156. DOI:10.1186/s12885-017-3126-7
[2] Hou Z, et al. Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site. Eur J Med Chem. 2017 May 26;132:1-10. DOI:10.1016/j.ejmech.2017.03.023
[3] Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306. DOI:10.3892/ol.2018.8529
[4] Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. DOI:10.1097/CRD.0b013e31822b4939
[5] Jabeen E, et al. Interaction of antihypertensive acetazolamide with nonsteroidal anti-inflammatory drugs. J Photochem Photobiol B. 2013 Aug 5;125:155-63. DOI:10.1016/j.jphotobiol.2013.06.002
[6] Abutaleb NS, et al. In vivo efficacy of acetazolamide in a mouse model of Neisseria gonorrhoeae infection. Microb Pathog. 2022 Mar;164:105454. DOI:10.1016/j.micpath.2022.105454

ACETAZOLAMIDE SODIUM Preparation Products And Raw materials

Raw materials

Preparation Products

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ACETAZOLAMIDE SODIUM Suppliers

China 11 India 2 South Korea 1 United States 6 Global 20

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
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AFINE CHEMICALS LIMITED

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Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
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Country: China
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TargetMol Chemicals Inc.

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Country: China
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Shanghai Yifei Biotechnology Co. , Ltd.

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Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

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RD International Technology Co., Limited

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Sangon Biotech (Shanghai) Co.,Ltd.

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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

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Chongqing jooe co., ltd

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1424-27-7, ACETAZOLAMIDE SODIUMRelated Search:

Acetazolamide 5-(ETHYLAMINO)-1,3,4-THIADIAZOLE-2-THIOL 2-Acetylamino-5-mercapto-1,3,4-thiadiazole ACETAZOLAMIDE SODIUM 5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE

ACETAZOLAMIDE SODIUM

acetazolamidesodiumsalt

diamoxsodium

n-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt

n-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamidmonosodiumsalt

SODIUMACETAZOLAMIDE

1424-27-7

C4H5N4O3S2Na

C4H5N4NaO3S2