ChemicalBook > CAS DataBase List > 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea

1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea

Product Name
1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
CAS No.
1997387-43-5
Chemical Name
1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
Synonyms
PZM-21;PZM 21; PZM-21;Opioid Receptor,Inhibitor,PZM21,inhibit,PZM 21,PZM-21;1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea;1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea;Urea, N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]-
CBNumber
CB83137417
Molecular Formula
C19H27N3O2S
Formula Weight
361.5
MOL File
1997387-43-5.mol
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1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Property

Boiling point:
583.8±50.0 °C(Predicted)
Density 
1.169±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);276.63(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);27.7(Max Conc. mM)
form 
A crystalline solid
pka
10.06±0.15(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20576
Product name
PZM21
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
20576
Product name
PZM21
Packaging
25mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
20576
Product name
PZM21
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
20576
Product name
PZM21
Packaging
10mg
Price
$164
Updated
2024/03/01
Tocris
Product number
7218
Product name
PZM21
Purity
≥98%(HPLC)
Packaging
10
Price
$199
Updated
2021/12/16
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1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Chemical Properties,Usage,Production

Uses

PZM21 is a potent Gi activator with exceptional selectivity for μOR and minimal β-arrestin-2 recruitment. PZM21 is an experimental opioid analgesic drug that is being researched for the treatment of pain. It is a functionally selective μ-opioid receptor agonist which produces μ-opioid receptor mediated G protein signaling, with potency and efficacy similar to morphine, but with less β-arrestin 2 recruitment. In tests on mice, PZM21 was slightly less potent than morphine or TRV130 as an analgesic, but also had significantly reduced adverse effects, with less constipation than morphine, and very little respiratory depression, even at high doses.

storage

Store at -20°C

1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea Suppliers

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1997387-43-5, 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)ureaRelated Search:


  • 1-((S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl)-3-((S)-1-(thiophen-3-yl)propan-2-yl)urea
  • PZM-21
  • PZM 21; PZM-21
  • 1-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea
  • Urea, N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]-
  • Opioid Receptor,Inhibitor,PZM21,inhibit,PZM 21,PZM-21
  • 1997387-43-5