ChemicalBook > CAS DataBase List > 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- Product Name
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- CAS No.
- 1207836-10-9
- Chemical Name
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- Synonyms
- LOXO-292 intermediate;6-Bromo-4-methoxypyrazoL;Selpercatinib intermediate;o[1,5-a]pyridine-3-carbonitriL;6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonit;6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile;6-bromo-4-methoxypyrazolol[.5-alpyridine-3-carbonitrile;6-bromo-4-methoxypyrazole[1,5-a]pyridine-3-carbonitrile;6-Bromo-4-methoxypyrazolo [1,5-A] pyridine-3-acetonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-methoxy-
- CBNumber
- CB83143962
- Molecular Formula
- C9H6BrN3O
- Formula Weight
- 252.07
- MOL File
- 1207836-10-9.mol
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6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Property
- Density
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -1.97±0.30(Predicted)
- InChI
- InChI=1S/C9H6BrN3O/c1-14-8-2-7(10)5-13-9(8)6(3-11)4-12-13/h2,4-5H,1H3
- InChIKey
- JTEWRYBKHXGXHP-UHFFFAOYSA-N
- SMILES
- C12=C(C#N)C=NN1C=C(Br)C=C2OC
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N-Bromosuccinimide Price
AK Scientific
- Product number
- 0400DP
- Product name
- 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- Packaging
- 5g
- Price
- $1275
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0621203
- Product name
- 6-BROMO-4-METHOXYPYRAZOLO[1,5-A]PYRIDINE-3-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.68
- Updated
- 2021/12/16
Ambeed
- Product number
- A866632
- Product name
- 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- Purity
- 95%
- Packaging
- 100g
- Price
- $920
- Updated
- 2021/12/16
Chemenu
- Product number
- CM325273
- Product name
- 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- Purity
- 95+%
- Packaging
- 100g
- Price
- $1263
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11373512
- Product name
- 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $1663
- Updated
- 2021/12/16
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6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties,Usage,Production
Uses
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is an organic intermediate for laboratory R&D processes.
Synthesis
The DMF 10L solution of 2,4,6-trimethylbenzenesulfonic acid 3-bromo-5-methoxypyridinamine salt 2000g (4.96mol, 1.0eq), 2-chloropropene cyanide (7.44mol, 1.5eq) was added with potassium carbonate 684g (4.96mol, 1.0eq) and stirred at 20-30°C for 8h. Then the mixtrue was heated with dropwise 1132g (7.44mol, 1.5eq) of diazabicyclo at 50-60°C for 20h. After the reaction is finished and poured into water 30 L at RT. the solution was filtered, washed with water and recrystallized in ethanol to give a pale yellow solid, 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (702g 56%).
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers
hebei hongtan Biotechnology Co., Ltd
- Product
- Selpercatinib intermediate 1207836-10-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-05-16
hebei hongtan Biotechnology Co., Ltd
- Product
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 1207836-10-9
- Price
- US $75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kg
- Release date
- 2024-05-17
Jinan Million Pharmaceutical Co., Ltd
- Product
- 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 1207836-10-9
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1200KG/M
- Release date
- 2023-08-11