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ON1231320

Product Name
ON1231320
CAS No.
1312471-39-8
Chemical Name
ON1231320
Synonyms
GBO-006;CS-2589;ON1231320;ON 1231320;ON-1231320;ON1231320, 10 mM in DMSO;2-((1H-Indol-5-yl)amino)-6-((2,4-difluorophenyl)sulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[(2,4-difluorophenyl)sulfonyl]-2-(1H-indol-5-ylamino)-8-methyl-;ON-1231320,breast,ON1231320,Apoptosis,G2/M,Polo-like Kinase (PLK),phase,ON 1231320,Inhibitor,negative,MDAMB-231,inhibit,U2OS,fibroblasts,mitosis,triple
CBNumber
CB83145906
Molecular Formula
C22H15F2N5O3S
Formula Weight
467.45
MOL File
1312471-39-8.mol
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ON1231320 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 25 mg/mL (53.48 mM; Need ultrasonic)
form 
Solid
color 
Light yellow to green yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals
Product number
DC9927
Product name
ON1231320
Purity
>98%
Packaging
250mg
Price
$1200
Updated
2021/12/16
DC Chemicals
Product number
DC9927
Product name
ON1231320
Purity
>98%
Packaging
1g
Price
$2500
Updated
2021/12/16
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ON1231320 Chemical Properties,Usage,Production

Uses

ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity[1][2].

Biological Activity

ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity[1][2]. ON1231320 (Compound 7ao) has no inhibitory activity against PLK1, PLK3 and PLK4 (all IC50>10 μM)[1]. ON1231320 (0-5 μM; 24 hours) activates programmed cell death in human tumor cells[1]. ON1231320 inhibits cell proliferation in 16 tumor cell lines (DU145, MCF-7, BT474, SK-OV-3, MIA-PaCa-2, SK-MEL-28, A549, U87, COLO-205, HELA, H1975, RAJI, U205, K562, GRANTA-519; IC50= 0.035-0.2 μM)[1]. ON1231320 does not appreciably inhibit tubulin polymerization[1]. ON1231320 does not affect normal human fibroblasts[2]. ON1231320 (Compound 7ao; 75 mg/kg; IP; alternate days (Q2D) for 20 days) results in significant inhibition of tumor growth[1].

in vivo

ON1231320 (Compound 7ao; 75 mg/kg; IP; alternate days (Q2D) for 20 days) results in significant inhibition of tumor growth[1].

Animal Model:6-8 week old NCR nu/nu female mice with MDAMB-231 triple negative breast cancer cells[1]
Dosage:75 mg/kg
Administration:IP; alternate days (Q2D) for 20 days
Result:Resulted in significant inhibition of tumor growth (86.5%)

IC 50

PLK2: 0.31 μM (IC50); PLK1: >10 μM (IC50); PLK3: >10 μM (IC50); PLK4: >10 μM (IC50)

References

[1]. M V Ramana Reddy, et al. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem. 2016 Feb 15;24(4):521-44. [2]. Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.

ON1231320 Preparation Products And Raw materials

Raw materials

Preparation Products

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ON1231320 Suppliers

China 42 United States 4 Global 46
Wuhan TCASChem Technology Co., Ltd.
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027-86697669 13986148687
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86-027-86697669
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sales@tcaschem.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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Shanghaizehan biopharma technology co., Ltd.
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021-61350663 13052117465
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021-61350662
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sales@zehanbiopharma.com
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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Medi-tech Bioscientific Co., Ltd.
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0519-83246372 13585352506
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0519-83246372
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Heze Development Zone chuangli Chemical Co., Ltd.
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0530-+86-530-529 6766，+86-15666160102 15666160102
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0530-529 6766
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info@chuangli-chem.com
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Shanghai Biopharmaleader Co., Ltd.
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+86 18721201413
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+86 (21) 5775-8967
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sales@biopharmaleader.com
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Twochem Co.Ltd.
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
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18081075745
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chemflowtech@sina.com
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1312471-39-8, ON1231320Related Search:

ON123300

  • ON1231320
  • CS-2589
  • GBO-006
  • ON 1231320;ON-1231320
  • Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[(2,4-difluorophenyl)sulfonyl]-2-(1H-indol-5-ylamino)-8-methyl-
  • ON-1231320,breast,ON1231320,Apoptosis,G2/M,Polo-like Kinase (PLK),phase,ON 1231320,Inhibitor,negative,MDAMB-231,inhibit,U2OS,fibroblasts,mitosis,triple
  • 2-((1H-Indol-5-yl)amino)-6-((2,4-difluorophenyl)sulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
  • ON1231320, 10 mM in DMSO
  • 1312471-39-8
  • 131247-39-8
  • C22H15F2N5O3S