ON1231320
- Product Name
- ON1231320
- CAS No.
- 1312471-39-8
- Chemical Name
- ON1231320
- Synonyms
- GBO-006;CS-2589;ON1231320;ON 1231320;ON-1231320;2-((1H-Indol-5-yl)amino)-6-((2,4-difluorophenyl)sulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[(2,4-difluorophenyl)sulfonyl]-2-(1H-indol-5-ylamino)-8-methyl-;ON-1231320,breast,ON1231320,Apoptosis,G2/M,Polo-like Kinase (PLK),phase,ON 1231320,Inhibitor,negative,MDAMB-231,inhibit,U2OS,fibroblasts,mitosis,triple
- CBNumber
- CB83145906
- Molecular Formula
- C22H15F2N5O3S
- Formula Weight
- 467.45
- MOL File
- 1312471-39-8.mol
ON1231320 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 25 mg/mL (53.48 mM; Need ultrasonic)
- form
- Solid
- color
- Light yellow to green yellow
N-Bromosuccinimide Price
- Product number
- DC9927
- Product name
- ON1231320
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- DC9927
- Product name
- ON1231320
- Purity
- >98%
- Packaging
- 1g
- Price
- $2500
- Updated
- 2021/12/16
ON1231320 Chemical Properties,Usage,Production
Biological Activity
ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity[1][2]. ON1231320 (Compound 7ao) has no inhibitory activity against PLK1, PLK3 and PLK4 (all IC50>10 μM)[1]. ON1231320 (0-5 μM; 24 hours) activates programmed cell death in human tumor cells[1]. ON1231320 inhibits cell proliferation in 16 tumor cell lines (DU145, MCF-7, BT474, SK-OV-3, MIA-PaCa-2, SK-MEL-28, A549, U87, COLO-205, HELA, H1975, RAJI, U205, K562, GRANTA-519; IC50= 0.035-0.2 μM)[1]. ON1231320 does not appreciably inhibit tubulin polymerization[1]. ON1231320 does not affect normal human fibroblasts[2]. ON1231320 (Compound 7ao; 75 mg/kg; IP; alternate days (Q2D) for 20 days) results in significant inhibition of tumor growth[1].
References
[1]. M V Ramana Reddy, et al. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem. 2016 Feb 15;24(4):521-44. [2]. Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.
ON1231320 Preparation Products And Raw materials
Raw materials
Preparation Products
ON1231320 Suppliers
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