ON1231320

Product Name: ON1231320
CAS No.: 1312471-39-8
Chemical Name: ON1231320
Synonyms: GBO-006;CS-2589;ON1231320;ON 1231320;ON-1231320;2-((1H-Indol-5-yl)amino)-6-((2,4-difluorophenyl)sulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[(2,4-difluorophenyl)sulfonyl]-2-(1H-indol-5-ylamino)-8-methyl-;ON-1231320,breast,ON1231320,Apoptosis,G2/M,Polo-like Kinase (PLK),phase,ON 1231320,Inhibitor,negative,MDAMB-231,inhibit,U2OS,fibroblasts,mitosis,triple
CBNumber: CB83145906
Molecular Formula: C22H15F2N5O3S
Formula Weight: 467.45
MOL File: 1312471-39-8.mol

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ON1231320 Property

storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (53.48 mM; Need ultrasonic)
form: Solid
color: Light yellow to green yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC9927
Product name: ON1231320
Purity: >98%
Packaging: 250mg
Price: $1200
Updated: 2021/12/16

DC Chemicals

Product number: DC9927
Product name: ON1231320
Purity: >98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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ON1231320 Chemical Properties,Usage,Production

Biological Activity

ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity[1][2]. ON1231320 (Compound 7ao) has no inhibitory activity against PLK1, PLK3 and PLK4 (all IC50>10 μM)[1]. ON1231320 (0-5 μM; 24 hours) activates programmed cell death in human tumor cells[1]. ON1231320 inhibits cell proliferation in 16 tumor cell lines (DU145, MCF-7, BT474, SK-OV-3, MIA-PaCa-2, SK-MEL-28, A549, U87, COLO-205, HELA, H1975, RAJI, U205, K562, GRANTA-519; IC50= 0.035-0.2 μM)[1]. ON1231320 does not appreciably inhibit tubulin polymerization[1]. ON1231320 does not affect normal human fibroblasts[2]. ON1231320 (Compound 7ao; 75 mg/kg; IP; alternate days (Q2D) for 20 days) results in significant inhibition of tumor growth[1].

References

[1]. M V Ramana Reddy, et al. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem. 2016 Feb 15;24(4):521-44. [2]. Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.

ON1231320 Preparation Products And Raw materials

Raw materials

Preparation Products

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ON1231320 Suppliers

China 28 United States 5 Global 33

BOC Sciences

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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1312471-39-8, ON1231320Related Search:

ON123300

ON1231320

CS-2589

GBO-006

ON 1231320;ON-1231320

Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[(2,4-difluorophenyl)sulfonyl]-2-(1H-indol-5-ylamino)-8-methyl-

ON-1231320,breast,ON1231320,Apoptosis,G2/M,Polo-like Kinase (PLK),phase,ON 1231320,Inhibitor,negative,MDAMB-231,inhibit,U2OS,fibroblasts,mitosis,triple

2-((1H-Indol-5-yl)amino)-6-((2,4-difluorophenyl)sulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

1312471-39-8

131247-39-8

C22H15F2N5O3S