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iMDK

Product Name
iMDK
CAS No.
881970-80-5
Chemical Name
iMDK
Synonyms
iMDK;iMDK, 10 mM in DMSO;3-[2-(4-Fluoro-benzyl)-imidazo[2,1-b]thiazol-6-yl]-chromen-2-one;3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one;3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-;inhibit,iMDK,midkine,factor,PI3K,NSCLC,growth,Inhibitor,Phosphoinositide 3-kinase,MDK
CBNumber
CB83146307
Molecular Formula
C21H13FN2O2S
Formula Weight
376.4
MOL File
881970-80-5.mol
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iMDK Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C, protect from light
solubility 
Limited solubility
pka
5.71±0.40(Predicted)
form 
Solid
color 
Off-white to yellow
InChI
InChI=1S/C21H13FN2O2S/c22-15-7-5-13(6-8-15)9-16-11-24-12-18(23-21(24)27-16)17-10-14-3-1-2-4-19(14)26-20(17)25/h1-8,10-12H,9H2
InChIKey
IWFKQTWYILKFGE-UHFFFAOYSA-N
SMILES
C1(=O)OC2=CC=CC=C2C=C1C1=CN2C=C(CC3=CC=C(F)C=C3)SC2=N1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M320748
Product name
iMDK
Packaging
2.5mg
Price
$195
Updated
2021/12/16
TRC
Product number
M320748
Product name
iMDK
Packaging
5mg
Price
$345
Updated
2021/12/16
Usbiological
Product number
255499
Product name
iMDK
Packaging
10mg
Price
$466
Updated
2021/12/16
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iMDK Chemical Properties,Usage,Production

Uses

iMDK is a small molecule inhibitor used to bind to midkine (MDK), a heparin binding growth factor that is expressed in malignant tumors.

Biological Activity

Cell permeable: yes', 'Primary Target
Midkine', 'Reversible: yes

in vivo

The combination treatment of iMDK ( (9 mg/kg/day; intraperitoneally injected with 100 μl) and PD0325901 (5 mg/kg; orally administered) effectively reduced lung tumor growth in a xenograft mouse model[1].

Animal Model:female BALB/c nude mice (6 week old) bearing H441 human lung cancer xenografts[1]
Dosage:iMDK (9 mg/kg) and PD0325901 (5 mg/kg)
Administration:Intraperitoneally injected with 100 μL iMDK everyday and/or orally administered PD0325901 five times per week (on days 1, 2, 3, 4, 5, 7, 8, 9, 10, 11)
Result:Reduced significantly volume of the tumors derived from H441 lung adenocarcinoma cells after the combination treatment with iMDK and PD0325901 compared to that of single compound in a xenograft mouse model.

storage

Store at +4°C

iMDK Preparation Products And Raw materials

Raw materials

Preparation Products

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iMDK Suppliers

China 26 United States 5 Global 31
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
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3358272972@qq.com
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China
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3277
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58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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9803
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58
Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 18101056239
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3193328036@qq.com
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China
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29759
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68
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
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15317229551
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QQ:3607245178
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15151849396@163.com
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China
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989
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
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China
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8140
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58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
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product02@bidepharm.com
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China
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59936
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58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
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sales@chemlab-tachizaki.com
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China
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2742
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Wuhan Jingkangen Biomedical Technology Co., Ltd
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13720134139 086-15871494362 13720134139
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orders@jknbiochem.com
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China
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6762
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
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China
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9835
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58
TargetMol Chemicals Inc.
Tel
15002134094
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marketing@targetmol.cn
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China
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29357
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58
Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026
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Sales@sangon.com
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China
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6710
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Merck KGaA
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21-20338288
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ordercn@merckgroup.com
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China
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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China
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6051
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Selleck Chemicals
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400-668-6834
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info@selleck.cn
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China
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6071
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Shenzhen Campbell Biotechnology Co., Ltd.
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18028747627
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CHINA
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191
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Guangzhou New Century Technology Co., Ltd.
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020-13113998854 13113998854
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1094589719@qq.com
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China
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145
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Guangzhou Yansai Biological Products Co., Ltd.
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13710209565
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CHINA
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122
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Guangzhou Ruifeng Biotechnology Co., Ltd.
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14715141318
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CHINA
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Absin Bioscience Inc.
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chenjw@absin.cn
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CHINA
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Proteintech China
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--
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Proteintech-CN@ptglab.com
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Shanghai Chaoyan Biotechnology Co., Ltd.
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--
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471161314@qq.com
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Xiamen Huijia Biological Technology Co., Ltd.
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Beijing Bolide Biotechnology Co., Ltd.
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1985563437@qq.com
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6525
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Beijing Chief-East Tech Co.,Ltd (Qwbio)
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--
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info@qwbio.com
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6912
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50
Shanghai Haoyang Biological Technology Co., Ltd.
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596799915@QQ.COM
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2905
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Shanghai Weiwei Biological Technology Co., Ltd.
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sales@wheybio.com
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4398
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881970-80-5, iMDKRelated Search:


  • iMDK
  • 3-[2-(4-Fluoro-benzyl)-imidazo[2,1-b]thiazol-6-yl]-chromen-2-one
  • 2H-1-Benzopyran-2-one, 3-[2-[(4-fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-
  • inhibit,iMDK,midkine,factor,PI3K,NSCLC,growth,Inhibitor,Phosphoinositide 3-kinase,MDK
  • 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
  • 3-(2-(4-Fluorobenzyl)imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one
  • iMDK, 10 mM in DMSO
  • 881970-80-5