M 24

Product Name: M 24
CAS No.: 477775-14-7
Chemical Name: M 24
Synonyms: Buloxibutid;AT2 Agonist C21;AT2R Agonist C21;AT2 Agonist C21 (M24);T2 Agonist Compound 21;AT2 receptor agonist C21;Buloxibutid, 10 mM in DMSO;AT2 receptor agonist C21,AT-2 receptor agonist C21;Butyl (3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophen-2-yl)sulfonylcarbamate;Carbamic acid, N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester
CBNumber: CB83146327
Molecular Formula: C23H29N3O4S2
Formula Weight: 475.62
MOL File: 477775-14-7.mol

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M 24 Property

Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 5 mg/mL (10.51 mM)
form: A solid
pka: 4.32±0.10(Predicted)
color: White to yellow
InChIKey: XTEOJPUYZWEXFI-UHFFFAOYSA-N
SMILES: C(OCCCC)(=O)NS(C1SC(CC(C)C)=CC=1C1=CC=C(CN2C=NC=C2)C=C1)(=O)=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0018094
Product name: AT2receptoragonistC21
Purity: 99.24%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0018094
Product name: AT2receptoragonistC21
Purity: 99.24%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0018094
Product name: AT2receptoragonistC21
Purity: 99.24%
Packaging: 25mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0018094
Product name: AT2receptoragonistC21
Purity: 99.24%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0018094
Product name: AT2receptoragonistC21
Purity: 99.24%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

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M 24 Chemical Properties,Usage,Production

Uses

Buloxibutid (AT2 receptor agonist C21) is a agentlike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively[1].

in vivo

Buloxibutid, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44mapk, enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats, and lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats^[1].

IC 50

AT2 Receptor: 0.4 nM (Ki); AT1 Receptor: >10 μM (Ki)

References

[1] Wan Y, et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem. 2004 Nov 18;47(24):5995-6008. DOI:10.1021/jm049715t
[2] Schwengel K, Namsolleck P, Lucht K, et al. Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl). 2016;94(8):957-966. DOI:10.1007/s00109-016-1406-3
[3] Fatima N, Patel S, Hussain T. Angiotensin AT2 Receptor is Anti-inflammatory and Reno-Protective in Lipopolysaccharide Mice Model: Role of IL-10. Front Pharmacol. 2021;12:600163. DOI:10.3389/fphar.2021.600163

M 24 Preparation Products And Raw materials

Raw materials

Preparation Products

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M 24 Suppliers

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477775-14-7, M 24Related Search:

AT2 receptor agonist C21

Carbamic acid, N-[[3-[4-(1H-imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)-2-thienyl]sulfonyl]-, butyl ester

AT2 Agonist C21

AT2 Agonist C21 (M24)

T2 Agonist Compound 21

Buloxibutid

AT2 receptor agonist C21,AT-2 receptor agonist C21

Butyl (3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophen-2-yl)sulfonylcarbamate

AT2R Agonist C21

Buloxibutid, 10 mM in DMSO

477775-14-7