ML 351
- Product Name
- ML 351
- CAS No.
- 847163-28-4
- Chemical Name
- ML 351
- Synonyms
- ML 351;5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile;5-(Methylamino)-2-(naphthalen-1-yl)oxazole-4-carbonitrile;4-Oxazolecarbonitrile, 5-(methylamino)-2-(1-naphthalenyl)-;Subarachnoid hemorrhage,inhibit,oxidative stress,ML-351,SAH,neuronal,Lipoxygenase,LOX,T1D,β-cell,ML 351,ML351,Inhibitor,non-obese diabetic
- CBNumber
- CB83146332
- Molecular Formula
- C15H11N3O
- Formula Weight
- 249.27
- MOL File
- 847163-28-4.mol
ML 351 Property
- Boiling point:
- 507.3±60.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- ≤5mg/ml in DMSO;25mg/ml in dimethyl formamide
- form
- powder
- pka
- -0.97±0.10(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1353
- Product name
- ML351
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $226
- Updated
- 2023/06/20
- Product number
- SML1353
- Product name
- ML351
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $901
- Updated
- 2023/06/20
- Product number
- 16119
- Product name
- ML351
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 16119
- Product name
- ML351
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 16119
- Product name
- ML-351
- Purity
- ≥98%
- Packaging
- 10 mg
- Price
- $221
- Updated
- 2024/03/01
ML 351 Chemical Properties,Usage,Production
Description
Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. ML351 is an inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2. ML351 was shown to be protective against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduced infarct size in an in vivo mouse model for ischemic stroke.
Uses
ML351 is a selective 12/15 LOX inhibitor (IC50 = 200 nM). Exhibits >250-fold selectivity over related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2. Protects against oxidative glutamate toxicity in mouse neuronal cells (HT-22) and reduces infarct size in a mouse ischemic stroke model.
Biochem/physiol Actions
ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. ML351 reduces infarct size in a mouse model of ischemic stroke.
storage
Store at -20°C
References
[1]. rai g, joshi n, perry s, et al. discovery of ml351, a potent and selective inhibitor of human 15-lipoxygenase-1. probe reports from the nih molecular libraries program [internet]. bethesda (md): national center for biotechnology information (us); 2010-2013 apr 15 [updated 2014 jan 13].
[2]. rai g, joshi n, jung je, et al. potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. j med chem. 2014 may 22;57(10):4035-48.
[3]. gaffney bj. lipoxygenases: structural principles and spectroscopy. annu rev biophys biomol struct. 1996;25:431-59.
ML 351 Preparation Products And Raw materials
Raw materials
Preparation Products
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