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LY2365109 (hydrochloride)

Product Name
LY2365109 (hydrochloride)
CAS No.
1779796-27-8
Chemical Name
LY2365109 (hydrochloride)
Synonyms
LY2365109 HCl;LY2365109 hydrochloride, 10 mM in DMSO;LY-2365109 hydrochloride (LY2365109 hydrochloride);2-((2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)(methyl)amino)acetic acid hydrochloride;neuroblastoma,Glycine transporters,LY2365109,Human,GlyT,LY-2365109 hydrochloride,LY 2365109,glycine,seizure,LY2365109 hydrochloride,LY-2365109,uptake,Inhibitor,inhibit
CBNumber
CB83146615
Molecular Formula
C22H28ClNO5
Formula Weight
421.92
MOL File
1779796-27-8.mol
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LY2365109 (hydrochloride) Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble to 100 mM in DMSO and to 50 mM in ethanol
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
L503118
Product name
LY2365109Hydrochloride
Packaging
10mg
Price
$160
Updated
2021/12/16
TRC
Product number
L503118
Product name
LY2365109Hydrochloride
Packaging
25mg
Price
$315
Updated
2021/12/16
ChemScene
Product number
CS-5829
Product name
LY2365109(hydrochloride)
Purity
99.32%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-5829
Product name
LY2365109(hydrochloride)
Purity
99.32%
Packaging
10mg
Price
$160
Updated
2021/12/16
Activate Scientific
Product number
AS118226
Product name
LY2365109 hydrochloride
Purity
98+%
Packaging
5mg
Price
$216
Updated
2021/12/16
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LY2365109 (hydrochloride) Chemical Properties,Usage,Production

Uses

LY 2365109 Hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor.

in vivo

LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine[1].
LY2365109 hydrochloride increases seizure thresholds in mice[2].

Animal Model:Male Sprague-Dawley rats (250-300 g)[1]
Dosage:0.3 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg, 30 mg/kg
Administration:Oral administration
Result:Produced dose-dependent elevations in CSF levels of glycine measured 1 h after dosing.

IC 50

hGlyT1: 15.8 nM nM (IC50)

storage

Desiccate at RT

LY2365109 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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LY2365109 (hydrochloride) Suppliers

China 33 India 1 United States 6 Global 40
Shanghai Lollane Biological Technology Co.,Ltd.
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1779796-27-8, LY2365109 (hydrochloride)Related Search:


  • LY2365109 HCl
  • neuroblastoma,Glycine transporters,LY2365109,Human,GlyT,LY-2365109 hydrochloride,LY 2365109,glycine,seizure,LY2365109 hydrochloride,LY-2365109,uptake,Inhibitor,inhibit
  • 2-((2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)phenoxy)ethyl)(methyl)amino)acetic acid hydrochloride
  • LY2365109 hydrochloride, 10 mM in DMSO
  • LY-2365109 hydrochloride (LY2365109 hydrochloride)
  • 1779796-27-8