N-Me-L-Ala-maytansinol

Product Name: N-Me-L-Ala-maytansinol
CAS No.: 77668-69-0
Chemical Name: N-Me-L-Ala-maytansinol
Synonyms: AP3 Intermidate;AP3 Intermidate 1;N-Me-L-Ala-maytansinol;Maytansine, N2'-deacetyl-;maytansinol 3-(S)-α-N-methylaminopropionate;Benzoicacid,4-fluoro-,(5-bromo-4-methoxyphenyl)methylester;(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl (2S)-2-(methylamino)propanoate
CBNumber: CB83147258
Molecular Formula: C32H44ClN3O9
Formula Weight: 650.17
MOL File: 77668-69-0.mol

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N-Me-L-Ala-maytansinol Property

Boiling point:: 849.5±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
pka: 9.82±0.70(Predicted)
form: Solid
color: White to off-white
InChIKey: ANHBJISROJTYCJ-CYVYAHHPNA-N

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Hazard and Precautionary Statements (GHS)

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N-Me-L-Ala-maytansinol Chemical Properties,Usage,Production

Description

Maytansinoid-Ala is a potent microtubule-targeted compound that inhibits proliferation of cells at mitosis. Maytansinoid-Ala can be used for synthesis of ADCs. The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules.

Uses

N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used for making antibody-drug conjugate (ADC)[1].

IC 50

Maytansinoids

References

[1] Nittoli T, et al. Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids. Bioorg Med Chem. 2018 May 15;26(9):2271-2279. DOI:10.1016/j.bmc.2018.02.025

N-Me-L-Ala-maytansinol Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Me-L-Ala-maytansinol Suppliers

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View Lastest Price from N-Me-L-Ala-maytansinol manufacturers

Jiangsu Nata Opto-electronic Material Co.,Ltd.

Product: N-Me-L-Ala-maytansinol 77668-69-0
Price: US $0.00/G
Min. Order: 5G
Purity: 98%
Supply Ability: 1KG
Release date: 2023-05-24

77668-69-0, N-Me-L-Ala-maytansinolRelated Search:

N-ACETYLLACTOSAMINE

AP3 Intermidate 1

maytansinol 3-(S)-α-N-methylaminopropionate

AP3 Intermidate

N-Me-L-Ala-maytansinol

Maytansine, N2'-deacetyl-

Benzoicacid,4-fluoro-,(5-bromo-4-methoxyphenyl)methylester

(1S,2R,3S,5S,6R,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.11?,1?.03,?]hexacosa-10,12,14(26),16,18-pentaen-6-yl (2S)-2-(methylamino)propanoate

77668-69-0

C32H44ClN3O9