S63845

Product Name: S63845
CAS No.: 1799633-27-4
Chemical Name: S63845
Synonyms: S63845;CS-2485;CS-2477;S63845 TFA;S 63845;S-63845;S63845, 10 mM in DMSO;Inhibitor,S63845,S-63845,S 63845,Bcl-2 Family,inhibit;(2R)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid
CBNumber: CB83147768
Molecular Formula: C39H37ClF4N6O6S
Formula Weight: 829.26
MOL File: 1799633-27-4.mol

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S63845 Property

Boiling point:: 852.6±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light, stored under nitrogen
solubility: insoluble in H2O; ≥20 mg/mL in MeOH; ≥41.45 mg/mL in DMSO
form: A crystalline solid
pka: 2.54±0.11(Predicted)
color: White to yellow
InChIKey: ZFBHXVOCZBPADE-JZEPPUFONA-N
SMILES: C1C=C(OCC2=CC=NN2CC(F)(F)F)C(C[C@@H](OC2C3C(C4C=CC(OCCN5CCN(C)CC5)=C(Cl)C=4C)=C(C4=CC=C(F)O4)SC=3N=CN=2)C(=O)O)=CC=1 |&1:17,r|

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21131
Product name: S63845
Purity: ≥98%
Packaging: 500μg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 21131
Product name: S63845
Purity: ≥98%
Packaging: 1mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 21131
Product name: S63845
Purity: ≥98%
Packaging: 5mg
Price: $212
Updated: 2024/03/01

ApexBio Technology

Product number: A8737
Product name: S63845
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ApexBio Technology

Product number: A8737
Product name: S63845
Packaging: 25mg
Price: $1000
Updated: 2021/12/16

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S63845 Chemical Properties,Usage,Production

Description

S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1; K_i = 0.19 nM), a pro-survival protein that is overexpressed in many cancers. It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC₅₀s = <0.1-282 nM) via mitochondrial apoptosis. S63845 acts synergistically with trametinib , lapatinib , PLX4032 , and erlotinib to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively. S63845 (6.25-25 mg/kg) reduces tumor volume in an MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner.

Uses

S-63845 is used in killing senescent cells and treating senescence-associated diseases or disorders using a combination of a BCL inhibitor and an MCL-1 inhibitor.Potent and selective MCL1 inhibitor

in vivo

S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers. Intravenously injected (i.v.) S63845 exerts dose-dependent anti-tumour activity in human multiple myeloma (H929 and AMO1) xenografts in immunocompromised mice, with maximal tumour growth inhibition of 114% in the AMO1 model and 103% in the H929 model. At 25 mg/kg, S63845 induces complete regression in 7 out of 8 of the mice at 100 days after treatment in the AMO1 model^[1].

IC 50

MCL1: 0.19 nM (Kd)

References

[1] ANDRáS KOTSCHY. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models[J]. Nature, 2016, 538 7626: 477-482. DOI: 10.1038/nature19830

S63845 Preparation Products And Raw materials

Raw materials

Preparation Products

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S63845 Suppliers

China 96 India 1 United Kingdom 1 United States 8 Global 106

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
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Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
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Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
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Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
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Shanghai YuanQi Biotechnology Co., Ltd.

Tel: +86-2332782371 +86-18120098618
Email: sales@adobechem.com
Country: China
ProdList: 1250
Advantage: 50

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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View Lastest Price from S63845 manufacturers

Career Henan Chemical Co

Product: S63845; 1799633-27-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

1799633-27-4, S63845Related Search:

S811 S5011

(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid

(2R)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid

Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-, (αR)-

S63845

S 63845;S-63845

CS-2477

CS-2485

S63845 TFA

(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid

Inhibitor,S63845,S-63845,S 63845,Bcl-2 Family,inhibit

S63845, 10 mM in DMSO

1799633-27-4

C39H37ClF4N6O6S

API