S63845
- Product Name
- S63845
- CAS No.
- 1799633-27-4
- Chemical Name
- S63845
- Synonyms
- S63845;CS-2485;CS-2477;S63845 TFA;S 63845;S-63845;Inhibitor,S63845,S-63845,S 63845,Bcl-2 Family,inhibit;(2R)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;(S)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid;Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-, (αR)-
- CBNumber
- CB83147768
- Molecular Formula
- C39H37ClF4N6O6S
- Formula Weight
- 829.26
- MOL File
- 1799633-27-4.mol
S63845 Property
- Boiling point:
- 852.6±65.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light, stored under nitrogen
- solubility
- insoluble in H2O; ≥20 mg/mL in MeOH; ≥41.45 mg/mL in DMSO
- form
- A crystalline solid
- pka
- 2.54±0.11(Predicted)
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21131
- Product name
- S63845
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 21131
- Product name
- S63845
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $104
- Updated
- 2024/03/01
- Product number
- 21131
- Product name
- S63845
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $212
- Updated
- 2024/03/01
- Product number
- A8737
- Product name
- S63845
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- A8737
- Product name
- S63845
- Packaging
- 25mg
- Price
- $1000
- Updated
- 2021/12/16
S63845 Chemical Properties,Usage,Production
Description
S63845 is an inhibitor of myeloid cell leukemia 1 (Mcl-1; Ki = 0.19 nM), a pro-survival protein that is overexpressed in many cancers. It induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = <0.1-282 nM) via mitochondrial apoptosis. S63845 acts synergistically with trametinib , lapatinib , PLX4032 , and erlotinib to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively. S63845 (6.25-25 mg/kg) reduces tumor volume in an MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner.
Uses
S-63845 is used in killing senescent cells and treating senescence-associated diseases or disorders using a combination of a BCL inhibitor and an MCL-1 inhibitor.Potent and selective MCL1 inhibitor
S63845 Preparation Products And Raw materials
Raw materials
Preparation Products
S63845 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
View Lastest Price from S63845 manufacturers
- Product
- S63845; 1799633-27-4
- Price
- US $1.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31