(2R)-Octyl-α-hydroxyglutarate
- Product Name
- (2R)-Octyl-α-hydroxyglutarate
- CAS No.
- 1391194-67-4
- Chemical Name
- (2R)-Octyl-α-hydroxyglutarate
- Synonyms
- Octyl-(R)-2HG;(2R)-Octyl-2-HG;(2R)-Octyl-a-hydroxyglutarate;(2R)-Octyl-α-hydroxyglutarate;(2R)-Octyl-.alpha.-hydroxyglutarate;(4R)-4-hydroxy-5-octoxy-5-oxopentanoic acid;(R)-2-Hydroxy-pentanedioic acid 1-octyl ester;(R)-4-Hydroxy-5-(octyloxy)-5-oxopentanoic acid;(2R)-2-Hydroxy-pentanedioic acid 1-octyl ester;Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2R)-
- CBNumber
- CB83152418
- Molecular Formula
- C13H24O5
- Formula Weight
- 260.33
- MOL File
- 1391194-67-4.mol
(2R)-Octyl-α-hydroxyglutarate Property
- storage temp.
- -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 1 mg/ml
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML2200
- Product name
- Octyl-(R)-2HG
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $131
- Updated
- 2024/03/01
- Product number
- SML2200
- Product name
- Octyl-(R)-2HG
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $530
- Updated
- 2024/03/01
- Product number
- 16366
- Product name
- (2R)-Octyl-α-hydroxyglutarate
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- 16366
- Product name
- (2R)-Octyl-α-hydroxyglutarate
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $231
- Updated
- 2024/03/01
- Product number
- 16366
- Product name
- (2R)-Octyl-α-hydroxyglutarate
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $410
- Updated
- 2024/03/01
(2R)-Octyl-α-hydroxyglutarate Chemical Properties,Usage,Production
Uses
(2R)-Octyl-α-hydroxyglutarate is an octyl ester derivative of (2R)-2-Hydroxyglutaric Acid (H942565), a potential inhibitor of glutamate carboxypeptidase. It is used to examine the contribution of D-2HG to the mitochondrial processes of IDH1-mutated cancer cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research.
Biological Activity
Octyl-(R)-2HG (Octyl-D-2HG) is a membrane-permeant precursor form of the oncometabolite D-2-hydroxyglutarate (D-2HG) produced by tumor cells due to mutations in the NADP+-dependent isocitrate dehydrogenase genes IDH1 and IDH2. D-2HG inhibits multiple α-ketoglutarate/α-KG-dependent dioxygenases by competing against α-KG binding. Cellular D-2HG delivery by Octyl-(R)-2HG treatment (1-50 mM) is shown to suppress demethylase activity (~148% H3K9me2 and ~310% H3K79me2 upregulation; 50 mM in U-87MG) as well as increase HIF-1α and decrease endostatin levels as a result of inhibiting α-KG-dependent dioxygenases prolyl hydroxylases (PHDs) and collagen prolyl-4-hydroxylase (C-P4H), respectively.
(2R)-Octyl-α-hydroxyglutarate Preparation Products And Raw materials
Raw materials
Preparation Products
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