ChemicalBook > CAS DataBase List > ML-184

ML-184

Product Name: ML-184
CAS No.: 794572-10-4
Chemical Name: ML-184
Synonyms: ML-184;CID2440433;ML-184, 10 mM in DMSO;3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide;ML184,ML-184,inhibit,CID 2440433,ML 184,G protein-coupled receptor 55,CID-2440433,Inhibitor,GPR55;3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide;3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-(pyrrolidin-1-yl)benzene-1-sulfonamide;Benzenesulfonamide, 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-
CBNumber: CB83152685
Molecular Formula: C25H34N4O3S
Formula Weight: 470.63
MOL File: 794572-10-4.mol

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ML-184 Property

storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
form: A crystalline solid
color: White to off-white
InChI: InChI=1S/C25H34N4O3S/c1-19-8-7-9-23(20(19)2)28-14-16-29(17-15-28)25(30)22-18-21(33(31,32)26(3)4)10-11-24(22)27-12-5-6-13-27/h7-11,18H,5-6,12-17H2,1-4H3
InChIKey: VRSJAHQGJHDACS-UHFFFAOYSA-N
SMILES: C1(S(N(C)C)(=O)=O)=CC=C(N2CCCC2)C(C(N2CCN(C3=CC=CC(C)=C3C)CC2)=O)=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2884
Product name: ML184
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $78.18
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2884
Product name: ML184
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $333
Updated: 2025/07/31

Cayman Chemical

Product number: 17641
Product name: ML-184
Purity: ≥98%
Packaging: 1mg
Price: $26
Updated: 2024/03/01

Cayman Chemical

Product number: 17641
Product name: ML-184
Purity: ≥98%
Packaging: 25 mg
Price: $351
Updated: 2024/03/01

Cayman Chemical

Product number: 17641
Product name: ML-184
Purity: ≥98%
Packaging: 500μg
Price: $39
Updated: 2023/01/06

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ML-184 Chemical Properties,Usage,Production

Description

CID2440433, also known as ML-184, is a potent synthetic agonist of GPR55 (EC50 = 0.26 μM). GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 μM lysophosphatidylinositol (LPI).

Uses

ML-184 (CID2440433) is a selective GPR55 agonist with an EC50 of 250 nM and exhibits >100-fold selectivity for GPR55 over GPR35, CB1?and CB2. ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55[1]. ML-184(CID2440433) increases proliferation of neural stem cells and promotes neuronal differentiation?in vitro[2].

Definition

ChEBI: 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]-oxomethyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide is a member of piperazines.

storage

Store at +4°C

References

[1] Kotsikorou E, et al. Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47. DOI:10.1021/bi200010k
[2] Hill JD, et al. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. Br J Pharmacol. 2018 Aug;175(16):3407-3421. DOI:10.1111/bph.14387

ML-184 Preparation Products And Raw materials

Raw materials

Preparation Products

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794572-10-4, ML-184Related Search:

3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide

ML-184

3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide

3-[4-(2,3-dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-(pyrrolidin-1-yl)benzene-1-sulfonamide

Benzenesulfonamide, 3-[[4-(2,3-dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)-

CID2440433

ML184,ML-184,inhibit,CID 2440433,ML 184,G protein-coupled receptor 55,CID-2440433,Inhibitor,GPR55

ML-184, 10 mM in DMSO

794572-10-4