Syk Inhibitor II

Product Name: Syk Inhibitor II
CAS No.: 726695-51-8
Chemical Name: Syk Inhibitor II
Synonyms: Syk Inhibitor II, 10 mM in DMSO;2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-;ATP-competitive,Serotonin Receptor,antigen,inhibit,Spleen tyrosine kinase,Syk Inhibitor II,Anti-allergic,pyrimidine-carboxamide,Inhibitor,Syk,5-HT Receptor,5-hydroxytryptamine Receptor
CBNumber: CB83152751
Molecular Formula: C14H15F3N6O
Formula Weight: 340.3
MOL File: 726695-51-8.mol

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Syk Inhibitor II Property

Melting point:: 270-272 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))
Boiling point:: 541.6±60.0 °C(Predicted)
Density: 1.455±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMSO: 15 mg/ml
form: A crystalline solid
pka: 14.04±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18202
Product name: Syk Inhibitor II
Purity: ≥98%
Packaging: 500μg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 18202
Product name: Syk Inhibitor II
Purity: ≥98%
Packaging: 1mg
Price: $228
Updated: 2024/03/01

Cayman Chemical

Product number: 18202
Product name: Syk Inhibitor II
Purity: ≥98%
Packaging: 5mg
Price: $952
Updated: 2024/03/01

ChemScene

Product number: CS-0079263
Product name: SykInhibitorII
Purity: 98.05%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: 9765CQ
Product name: SykInhibitorII
Packaging: 1mg
Price: $351
Updated: 2021/12/16

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Syk Inhibitor II Chemical Properties,Usage,Production

Uses

Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect[1].

in vivo

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID₅₀ value of 13.2 mg/kg^[1].

IC 50

Syk: 41 nM (IC₅₀); serotonin: 460 nM (IC₅₀); PKCε: 5.1 μM (IC₅₀); PKCβ2: 11 μM (IC₅₀); ZAP-70: 11.2 μM (IC₅₀); Btk: 15.5 μM (IC₅₀); Itk: 22.6 μM (IC₅₀)

References

[1] Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. DOI:10.1016/j.bmc.2005.05.033

Syk Inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

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Syk Inhibitor II Suppliers

China 31 United States 4 Global 35

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726695-51-8, Syk Inhibitor IIRelated Search:

ATP-competitive,Serotonin Receptor,antigen,inhibit,Spleen tyrosine kinase,Syk Inhibitor II,Anti-allergic,pyrimidine-carboxamide,Inhibitor,Syk,5-HT Receptor,5-hydroxytryptamine Receptor

5-Pyrimidinecarboxamide, 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-

2-((2-Aminoethyl)amino)-4-((3-(trifluoromethyl)phenyl)amino)pyrimidine-5-carboxamide

Syk Inhibitor II, 10 mM in DMSO

726695-51-8