VLX600

Product Name: VLX600
CAS No.: 327031-55-0
Chemical Name: VLX600
Synonyms: Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone;6-methyl-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-[1,2,4]triazino[5,6-b]indole;6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine;iron,HCT116,Autophagy,glycolytic,VLX 600,colon,chelator,cancer,OXPHOS,VLX600,Mitochondrial Metabolism,proliferation,VLX-600,Inhibitor,oxidative phosphorylation,inhibit
CBNumber: CB83152766
Molecular Formula: C17H15N7
Formula Weight: 317.36
MOL File: 327031-55-0.mol

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VLX600 Property

Boiling point:: 590.9±58.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C,unstable in solution, ready to use.
solubility: ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid
pka: 7.53±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17192
Product name: VLX600
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17192
Product name: VLX600
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 17192
Product name: VLX600
Purity: ≥95%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 17192
Product name: VLX600
Purity: ≥95%
Packaging: 25mg
Price: $397
Updated: 2024/03/01

TRC

Product number: V757175
Product name: VLX600
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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VLX600 Chemical Properties,Usage,Production

Description

VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC₅₀ = 1-10 μM) with selectivity for malignant cells. It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells. VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.

Uses

VLX600 is a compound showing cytotoxicity against cancer cells. Selective towards malignant cells and necrosis inductor in colon cancer cells.

References

zhang x, frykns m, hernlund e, et al. induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. nat commun. 2014;5:3295.

VLX600 Preparation Products And Raw materials

Raw materials

Preparation Products

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VLX600 Suppliers

China 18 United States 6 Global 24

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2992
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7298
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988968278
Fax: QQ：3283937693
Email: sales@ubiochem.com
Country: China
ProdList: 4297
Advantage: 58

327031-55-0, VLX600Related Search:

VLX1570

6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine

6-methyl-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-[1,2,4]triazino[5,6-b]indole

Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone

iron,HCT116,Autophagy,glycolytic,VLX 600,colon,chelator,cancer,OXPHOS,VLX600,Mitochondrial Metabolism,proliferation,VLX-600,Inhibitor,oxidative phosphorylation,inhibit

327031-55-0