VLX600
- Product Name
- VLX600
- CAS No.
- 327031-55-0
- Chemical Name
- VLX600
- Synonyms
- Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone;6-methyl-3-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-[1,2,4]triazino[5,6-b]indole;6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine;iron,HCT116,Autophagy,glycolytic,VLX 600,colon,chelator,cancer,OXPHOS,VLX600,Mitochondrial Metabolism,proliferation,VLX-600,Inhibitor,oxidative phosphorylation,inhibit
- CBNumber
- CB83152766
- Molecular Formula
- C17H15N7
- Formula Weight
- 317.36
- MOL File
- 327031-55-0.mol
VLX600 Property
- Boiling point:
- 590.9±58.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- solubility
- ≤1mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 7.53±0.70(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17192
- Product name
- VLX600
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 17192
- Product name
- VLX600
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 17192
- Product name
- VLX600
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 17192
- Product name
- VLX600
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $397
- Updated
- 2024/03/01
- Product number
- V757175
- Product name
- VLX600
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
VLX600 Chemical Properties,Usage,Production
Description
VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 μM) with selectivity for malignant cells. It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells. VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.
Uses
VLX600 is a compound showing cytotoxicity against cancer cells. Selective towards malignant cells and necrosis inductor in colon cancer cells.
References
zhang x, frykns m, hernlund e, et al. induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. nat commun. 2014;5:3295.
VLX600 Preparation Products And Raw materials
Raw materials
Preparation Products
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