Nintedanib impurity E
- Product Name
- Nintedanib impurity E
- CAS No.
- 262366-32-5
- Chemical Name
- Nintedanib impurity E
- Synonyms
- Intedanib Impurity E;Nintedanib impurity E;Desmethoxycarbonyl Nintedanib;1-Piperazineacetamide, N-[4-[[(Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-;Nintedanib impurity 23/N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide
- CBNumber
- CB83154472
- Molecular Formula
- C29H31N5O2
- Formula Weight
- 481.59
- MOL File
- 262366-32-5.mol
Nintedanib impurity E Property
- solubility
- DMSO (Very Slightly)
- form
- Solid
- color
- Pale Yellow to Light Yellow
N-Bromosuccinimide Price
- Product number
- D452513
- Product name
- N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide
- Packaging
- 2.5mg
- Price
- $105
- Updated
- 2021/12/16
Nintedanib impurity E Chemical Properties,Usage,Production
Uses
N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide was used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.
Synthesis
1)(Z)-3-{1-[4-(N-(4-benzylpiperazinylmethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylene}-2-dihydroindolone
Prepared from 1-acetyl-3-(1-ethoxy-1-phenyl-methylene)-2-dihydroindolone and 4-[N-(4-benzylpiperazinylmethyl-carbonyl)-N-methyl-amino]-aniline in DMF, followed by treatment with methanolic solution of sodium hydroxide.
2) (Z)-3-{1-[4-(N-piperazinylmethylcarbonyl-N-methyl-amino)-phenyl-amino]-1-phenyl-methylene}-2-dihydroindolone-dihydrochloride (nidanib impurity E)
390 mg (0.7 mmol) of (Z)-3-{1-[4-(N-(N-benzylpiperazinylmethylcarbonyl)-N-methyl-amino)-phenylamino]-1-phenyl-methylene}-2-dihydroindolone was dissolved in 20 ml of dichloromethane, heated for 30 min at room temperature after the addition of 0.2 g (1.4 mmol) of chloroethyl 1-chloroformate and refluxed for 60 min. The solvent was concentrated by evaporation and the residue was mixed with 10 ml of methanol and refluxed for 90 minutes. After stirring for 18 hours at room temperature, the product was filtered by suction, washed with methanol and dried. Nidanib impurity E Yield: 200 mg (51% of theoretical value)
Nintedanib impurity E Preparation Products And Raw materials
Raw materials
Preparation Products
Nintedanib impurity E Suppliers
- Tel
- 0-2022843681 15618226720
- Fax
- +86-21-51601218
- chaolaichem@foxmail.com
- Country
- China
- ProdList
- 10408
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3282
- Advantage
- 58
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3061
- Advantage
- 58
- Tel
- 0531-58897130 15508676053
- drug_impurity@sdcclh.com
- Country
- China
- ProdList
- 2291
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 0531-88987162 18615427082
- 2823799053@qq.com
- Country
- China
- ProdList
- 544
- Advantage
- 58
- Tel
- +86-020-81960175-877 4000-868-328
- tianwen.zhan@cato-chem.com
- Country
- United States
- ProdList
- 10404
- Advantage
- 58
View Lastest Price from Nintedanib impurity E manufacturers
- Product
- Nintedanib impurity E
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98%
- Supply Ability
- 500mg
- Release date
- 2024-08-06