ChemicalBook > CAS DataBase List > SF2523

SF2523

Product Name: SF2523
CAS No.: 1174428-47-7
Chemical Name: SF2523
Synonyms: SF2523;SF-2523;CS-2518;SF-2523; SF 2523;SF2523, 10 mM in DMSO;3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one;7H-Thieno[3,2-b]pyran-7-one, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)-;SF 2523,Inhibitor,PI3K,SF-2523,Phosphoinositide 3-kinase,Epigenetic Reader Domain,DNA-dependent protein kinase,DNA-PK,inhibit,SF2523
CBNumber: CB83158526
Molecular Formula: C19H17NO5S
Formula Weight: 371.41
MOL File: 1174428-47-7.mol

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SF2523 Property

Boiling point:: 538.0±50.0 °C(Predicted)
Density: 1.423±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:10.0(Max Conc. mg/mL);26.92(Max Conc. mM)
DMSO:29.5(Max Conc. mg/mL);79.43(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.27(Max Conc. mM)
Ethanol:7.0(Max Conc. mg/mL);18.85(Max Conc. mM)
form: A crystalline solid
pka: 0.55±0.20(Predicted)
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21638
Product name: SF2523
Purity: ≥98%
Packaging: 500μg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 21638
Product name: SF2523
Purity: ≥98%
Packaging: 1mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 21638
Product name: SF2523
Purity: ≥98%
Packaging: 5mg
Price: $388
Updated: 2024/03/01

Cayman Chemical

Product number: 21638
Product name: SF2523
Purity: ≥98%
Packaging: 10mg
Price: $723
Updated: 2024/03/01

Usbiological

Product number: 466057
Product name: SF2523
Packaging: 1mg
Price: $305
Updated: 2021/12/16

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SF2523 Chemical Properties,Usage,Production

Uses

SF2523 is a dual action inhibitor that blocks tumor growth and metastasis and for the development of anticancer therapy.

in vivo

SF2523 treatment results in a significant reduction of tumor volume compared with control. Importantly, SF2523 shows no gross toxicity to the treated mice, as there is no notable change in body weight. Tumors from SF2523-treated mice have markedly reduced MYCN, pAKT, and Cyclin D1 levels compared with levels of these proteins in vehicle-treated mice tumors^[2].

IC 50

PI3Kα: 34 nM (IC₅₀); PI3Kγ: 158 nM (IC₅₀); BRD4 (BD1): 241 nM (IC₅₀); DNA-PK: 9 nM (IC₅₀); mTOR: 280 nM (IC₅₀)

SF2523 Preparation Products And Raw materials

Raw materials

Preparation Products

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1174428-47-7, SF2523Related Search:

SF2523

SF-2523

3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-morpholino-7H-thieno[3,2-b]pyran-7-one

SF-2523; SF 2523

CS-2518

7H-Thieno[3,2-b]pyran-7-one, 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(4-morpholinyl)-

SF 2523,Inhibitor,PI3K,SF-2523,Phosphoinositide 3-kinase,Epigenetic Reader Domain,DNA-dependent protein kinase,DNA-PK,inhibit,SF2523

SF2523, 10 mM in DMSO

1174428-47-7