ChemicalBook > CAS DataBase List > KYA1797K

KYA1797K

Product Name
KYA1797K
CAS No.
1956356-56-1
Chemical Name
KYA1797K
Synonyms
CS-2581;KYA1797K;KYA1797K, 10 mM in DMSO;KYA1797K potassium salt;KYA1797K potassium salt >=98% (HPLC);Wnt,KYA1797K,Beta catenin,β-catenin,inhibit,Inhibitor,KYA-1797K;(5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt;Potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate (1:1)
CBNumber
CB83159457
Molecular Formula
C17H11KN2O6S2
Formula Weight
442.50734
MOL File
1956356-56-1.mol
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KYA1797K Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: Partially soluble; DMSO: 0.5 mg/ml; Ethanol: Partially soluble; PBS (pH 7.2): 0.3 mg/ml
form 
A crystalline solid
color 
Yellow to orange
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29221
Product name
KYA1797K
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
29221
Product name
KYA1797K
Packaging
50mg
Price
$553
Updated
2024/03/01
Cayman Chemical
Product number
29221
Product name
KYA1797K
Packaging
10mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
29221
Product name
KYA1797K
Packaging
25mg
Price
$317
Updated
2024/03/01
Tocris
Product number
7002
Product name
KYA1797K
Purity
≥98%(HPLC)
Packaging
25
Price
$295
Updated
2021/12/16
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KYA1797K Chemical Properties,Usage,Production

Uses

KYA1797K is a potent and selective Wnt/β-catenin inhibitor with an IC50 of 0.75 μM.

in vivo

KYA1797K significantly suppresses tumor growth and progression both in mouse xenografts of CRC cells harboring APC and K-Ras mutations and in an Apcmin/+/KRASG12DLA2 mouse model. KYA1797K administration (25 mg/kg) reduces both weight and volume of the tumor by 70%. KYA1797K treatment significantly reduces levels of β-catenin and Ras proteins as well as Wnt/β-catenin and Ras signaling targets [1].

storage

Store at -20°C

References

[1] Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600. DOI:10.1038/nchembio.2103

KYA1797K Preparation Products And Raw materials

Raw materials

Preparation Products

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KYA1797K Suppliers

China 66 India 1 United States 7 Global 74
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
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View Lastest Price from KYA1797K manufacturers

Career Henan Chemical Co
Product
KYA1797K 1956356-56-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

1956356-56-1, KYA1797KRelated Search:


  • KYA1797K
  • CS-2581
  • (5Z)-5-[[5-(4-Nitrophenyl)-2-furanyl]methylene]-4-oxo-2-thioxo-3-thiazolidinepropanoic acid potassium salt
  • KYA1797K potassium salt >=98% (HPLC)
  • Wnt,KYA1797K,Beta catenin,β-catenin,inhibit,Inhibitor,KYA-1797K
  • Potassium (Z)-3-(5-((5-(4-nitrophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)propanoate (1:1)
  • KYA1797K potassium salt
  • KYA1797K, 10 mM in DMSO
  • 1956356-56-1