Asapiprant
- Product Name
- Asapiprant
- CAS No.
- 932372-01-5
- Chemical Name
- Asapiprant
- Synonyms
- CS-2811;S555739;S 555739;S-555739;Asapiprant,S-555739;Asapiprant(BGE-175);Asapiprant, 10 mM in DMSO;S-555739; S 555739; S555739; ASAPIPRANT;S-555739; S 555739; S555739; ASAPIPRANT;932372-01-5;S 555739,Asapiprant,Prostaglandin Receptor,inhibit,S555739,Inhibitor,S-555739
- CBNumber
- CB83159947
- Molecular Formula
- C24H27N3O7S
- Formula Weight
- 501.55
- MOL File
- 932372-01-5.mol
Asapiprant Property
- Melting point:
- >218°C (dec.)
- Boiling point:
- 731.6±70.0 °C(Predicted)
- Density
- 1.341±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 2.92±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- 30008
- Product name
- Asapiprant
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 30008
- Product name
- Asapiprant
- Packaging
- 10mg
- Price
- $348
- Updated
- 2024/03/01
- Product number
- 30008
- Product name
- Asapiprant
- Packaging
- 5mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 30008
- Product name
- Asapiprant
- Packaging
- 25mg
- Price
- $535
- Updated
- 2024/03/01
- Product number
- A790165
- Product name
- Asapiprant
- Packaging
- 25mg
- Price
- $2810
- Updated
- 2021/12/16
Asapiprant Chemical Properties,Usage,Production
Uses
Asapiprant is a DP1 receptor antagonist, used in the treatment of asthma.
in vivo
Oral administration of Asapiprant to sheep at 1 and 3 mg/kg significantly (P<0.01) suppresses the increase in nasal resistance by 82% and 92%, respectively. Oral administration of Asapiprant to sheep at 5 mg/kg suppresses Prostaglandin (PG) D2 (PGD)2-induced nasal resistance by 86%. When orally administered 1 h before the antigen challenge in pigs, Asapiprant (3, 10, and 30 mg/kg) suppresses immediate airway response (IAR) by 52%, 57%, and 96%, and late airway response (LAR) by 67%, 50%, and 79%, respectively. Orally administered with Asapiprant (5 mg/kg) for 4 days, the Asapiprant significantly (P<0.01) suppresses antigen-induced nasal resistance by 73% in sheep. Treatment with 3 and 30 mg/kg of Asapiprant in pigs significantly (P<0.01) suppresses nasal secretion by 53% and 72%, respectively. Treatment with Asapiprant in rats at 10 mg/kg significantly (P<0.05) reduces airway hyper-responsiveness (AHR), infiltration of inflammatory cells, and mucin production in bronchoalveolar lavage fluid (BALF), although treatment with Asapiprant at 0.1 mg/kg does not have a significant effect on any responses[1].
IC 50
DP1: 0.44 nM (Ki)
Asapiprant Preparation Products And Raw materials
Raw materials
Preparation Products
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