(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate

Product Name: (6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
CAS No.: 313369-26-5
Chemical Name: (6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
Synonyms: LUMAT-007;Lumepirone impurity 37;N-ethoxycarbonyl-3-methyl-2,3,6b(R),7,8,9,10,10a(S)-octahydropyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline;N-ethoxycarbonyl-3-methyl-2,3,6b(R),7,8,9,10,10a(S)-octahydropyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline;Ethyl (6bR,10aS)-3-Methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3’,4’:4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate;Ethyl (6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate;(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate;1H-Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylic acid, 2,3,6b,9,10,10a-hexahydro-3-methyl-, ethyl ester, (6bR,10aS)-
CBNumber: CB83161681
Molecular Formula: C17H23N3O2
Formula Weight: 301.38
MOL File: 313369-26-5.mol

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(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate Property

storage temp.: Sealed in dry,Room Temperature
InChI: InChI=1S/C17H23N3O2/c1-3-22-17(21)19-8-7-14-13(11-19)12-5-4-6-15-16(12)20(14)10-9-18(15)2/h4-6,13-14H,3,7-11H2,1-2H3/t13-,14-/m0/s1
InChIKey: WHCUAJCNKSIETM-KBPBESRZSA-N
SMILES: N1(C)C2=C3C([C@]4([H])CN(C(OCC)=O)CC[C@]4([H])N3CC1)=CC=C2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 4900CZ
Product name: Ethyl(10R,15S)-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene-12-carboxylate
Packaging: 1g
Price: $1545
Updated: 2021/12/16

Ambeed

Product number: A105586
Product name: (6bR,10aS)-Ethyl3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
Purity: 97%
Packaging: 100mg
Price: $68
Updated: 2021/12/16

Ambeed

Product number: A105586
Product name: (6bR,10aS)-Ethyl3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
Purity: 97%
Packaging: 250mg
Price: $108
Updated: 2021/12/16

Ambeed

Product number: A105586
Product name: (6bR,10aS)-Ethyl3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
Purity: 97%
Packaging: 1g
Price: $269
Updated: 2021/12/16

Crysdot

Product number: CD00004813
Product name: (6bR,10aS)-Ethyl3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
Purity: 97%
Packaging: 100mg
Price: $359
Updated: 2021/12/16

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(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate Chemical Properties,Usage,Production

Synthesis

313369-25-4

313369-26-5

Step CA: Under nitrogen protection, borane tetrahydrofuran solution (1 M, 33 mL, 33 mmol) was slowly added dropwise to a stirred solution of (6bR,10aS)-3-methyl-2-oxo-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylic acid tertiary butyl ester (5.24 g, 16.6 mmol) in a solution of anhydrous tetrahydrofuran (25 mL). After dropwise addition, the reaction mixture was heated to reflux for 1 hour. After cooling, 6N hydrochloric acid (15 mL) was added and heating was continued under reflux conditions for 30 minutes. Upon completion of the reaction, the mixture was cooled and evaporated to dryness under reduced pressure. The residue was dissolved in a minimal amount of water, alkalized with 1N sodium hydroxide solution and extracted with dichloromethane (2×). The organic phases were combined, washed with water, dried over magnesium sulfate, and concentrated to give 4.65 g (93% yield) of tert-butyl (6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate as a viscous liquid.1H NMR ( CDCl3, 300MHz) δ 1.28 (t, J = 7Hz, 3H), 1.68-1.78 (m, 1H), 1.78-1.93 (m, 2H), 2.81-2.90 (m, 2H), 2.86 (s, 3H), 3.05-3.26 (m, 2H), 3.26-3.38 (m, 2H), 3.56- 3.75 (m, 2H), 3.79-3.87 (m, 1H), 4.16 (q, J = 7 Hz, 2H), 6.41 (d, J = 8.1 Hz, 1H), 6.61 (d, J = 8.1 Hz, 1H), 6.67 (t, J = 8.1 Hz, 1H) ppm. MS (CI): 302 (M + H+).

References

[1] Patent: US2004/220178, 2004, A1
[2] Patent: WO2008/112280, 2008, A1. Location in patent: Page/Page column 90-91
[3] Patent: WO2008/112280, 2008, A1. Location in patent: Page/Page column 90-91

(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate Suppliers

China 46 India 1 United States 2 Global 49

Chengdu D-innovation Pharmaceutical Co.，LTD

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YICHANG TIANRUI BIOPHARM CO., LTD

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Finetech Industry Limited

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Aikon International Limited

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Finetech Industry Limited

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View Lastest Price from (6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate manufacturers

Chengdu Aupone Pharmaceutical Co.Ltd.

Product: (6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate 313369-26-5
Price: US $0.00/kg
Min. Order: 5kg
Purity: 98.5
Supply Ability: 10Tons
Release date: 2024-06-14

313369-26-5, (6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylateRelated Search:

(6bR,10aS)-Ethyl 3-methyl-2-oxo-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate (3R,4R,5S)-4-N-Acetyl(1,1-dimethylethyl)amino-5-N,N-diallylamino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester monohydrochloride

(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate

LUMAT-007

Ethyl (6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate

Ethyl (6bR,10aS)-3-Methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3’,4’:4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate

1H-Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylic acid, 2,3,6b,9,10,10a-hexahydro-3-methyl-, ethyl ester, (6bR,10aS)-

N-ethoxycarbonyl-3-methyl-2,3,6b(R),7,8,9,10,10a(S)-octahydropyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

Lumepirone impurity 37

313369-26-5