4-(2-Aminopropan-2-yl)-1-Boc-piperidine

Product Name: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine
CAS No.: 530116-33-7
Chemical Name: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine
Synonyms: tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate;1-Boc-4-(2-amino-2-propyl)piperidine;4-(2-Aminopropan-2-yl)-1-Boc-piperidine;1-Boc-4-(1-amino-1-methylethyl)-piperidine;1-Piperidinecarboxylic acid, 4-(1-amino-1-methylethyl)-, 1,1-dimethylethyl ester
CBNumber: CB83166257
Molecular Formula: C13H26N2O2
Formula Weight: 242.36
MOL File: 530116-33-7.mol

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4-(2-Aminopropan-2-yl)-1-Boc-piperidine Property

Boiling point:: 320.6±15.0 °C(Predicted)
Density: 1.017±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.35±0.25(Predicted)
Appearance: light yellow liquid
InChI: InChI=1S/C13H26N2O2/c1-12(2,3)17-11(16)15-8-6-10(7-9-15)13(4,5)14/h10H,6-9,14H2,1-5H3
InChIKey: FXUHDTBFKFLRFO-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C(N)(C)C)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 292778
Product name: tert-Butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Packaging: 100.00mg
Price: $64
Updated: 2026/05/19

Matrix Scientific

Product number: 292778
Product name: tert-Butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Packaging: 250.00mg
Price: $98
Updated: 2026/05/19

Matrix Scientific

Product number: 292778
Product name: tert-Butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Packaging: 1.00g
Price: $258
Updated: 2026/05/19

Synthonix

Product number: B24102
Product name: tert-Butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Purity: 97%
Packaging: 100mg
Price: $100
Updated: 2026/05/06

Synthonix

Product number: B24102
Product name: tert-Butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Purity: 97%
Packaging: 250mg
Price: $140
Updated: 2026/05/06

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4-(2-Aminopropan-2-yl)-1-Boc-piperidine Chemical Properties,Usage,Production

Synthesis

917-54-4

91419-52-2

530116-33-7

General procedure for the synthesis of tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate from methyllithium and N-Boc-4-cyanopiperidine: firstly, cerium(III) chloride heptahydrate (25.5 g, 68.4 mmol) powder was stirred at 145 °C for 18 h under vacuum (<0.1 mmHg). After the solid was cooled to room temperature, THF (120 mL) was added and stirred at room temperature for 2 hours. Subsequently, the suspension was cooled to -78 °C and methyl lithium (45 mL, 1.4 M, dissolved in ether, 63 mmol) was added dropwise over 30 min. The reaction mixture was continued to be stirred at -78 °C for 30 min. A solution of 1-(tert-butoxycarbonyl)-4-cyanopiperidine (4.35 g, 20.7 mmol) in THF (15 mL) was slowly added via cannula, and the reaction was carried out at -78 °C for 4.5 hours. Upon completion of the reaction, ammonium hydroxide (40 mL) was added and the reaction mixture was slowly warmed to room temperature. After addition of dichloromethane (100 mL), the mixture was stirred at room temperature for 1 hour and then filtered through Celite. The Celite pad was washed with dichloromethane (3 x 50 mL). After combining the filtrates, the target product tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate was concentrated under reduced pressure to give tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate (5.0 g, 99% yield).

References

[1] Patent: US2004/10013, 2004, A1. Location in patent: Page/Page column 61

4-(2-Aminopropan-2-yl)-1-Boc-piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-Aminopropan-2-yl)-1-Boc-piperidine Suppliers

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530116-33-7, 4-(2-Aminopropan-2-yl)-1-Boc-piperidineRelated Search:

4-(2-Aminopropan-2-yl)-1-Boc-piperidine

1-Piperidinecarboxylic acid, 4-(1-amino-1-methylethyl)-, 1,1-dimethylethyl ester

1-Boc-4-(2-amino-2-propyl)piperidine

1-Boc-4-(1-amino-1-methylethyl)-piperidine

tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate

530116-33-7