4-(2-Aminopropan-2-yl)-1-Boc-piperidine

Product Name: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine
CAS No.: 530116-33-7
Chemical Name: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine
Synonyms: tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate;1-Boc-4-(2-amino-2-propyl)piperidine;4-(2-Aminopropan-2-yl)-1-Boc-piperidine;1-Boc-4-(1-amino-1-methylethyl)-piperidine;1-Piperidinecarboxylic acid, 4-(1-amino-1-methylethyl)-, 1,1-dimethylethyl ester
CBNumber: CB83166257
Molecular Formula: C13H26N2O2
Formula Weight: 242.36
MOL File: 530116-33-7.mol

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4-(2-Aminopropan-2-yl)-1-Boc-piperidine Property

Boiling point:: 320.6±15.0 °C(Predicted)
Density: 1.017±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.35±0.25(Predicted)
Appearance: light yellow liquid
InChI: InChI=1S/C13H26N2O2/c1-12(2,3)17-11(16)15-8-6-10(7-9-15)13(4,5)14/h10H,6-9,14H2,1-5H3
InChIKey: FXUHDTBFKFLRFO-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(C(N)(C)C)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 8327DN
Product name: 4-(2-Aminopropan-2-yl)-1-Boc-piperidine
Packaging: 100mg
Price: $239
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1052722
Product name: TERT-BUTYL-4-(2-AMINOPROPAN-2-YL)PIPERIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $505.2
Updated: 2021/12/16

Acrotein

Product number: UT02092
Product name: tert-Butyl4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $548.44
Updated: 2021/12/16

Chemenu

Product number: CM253442
Product name: tert-Butyl4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Purity: 97%
Packaging: 1g
Price: $837
Updated: 2021/12/16

Ambeed

Product number: A106176
Product name: tert-Butyl4-(2-aminopropan-2-yl)piperidine-1-carboxylate
Purity: 97%
Packaging: 100mg
Price: $108
Updated: 2021/12/16

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4-(2-Aminopropan-2-yl)-1-Boc-piperidine Chemical Properties,Usage,Production

Synthesis

917-54-4

91419-52-2

530116-33-7

General procedure for the synthesis of tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate from methyllithium and N-Boc-4-cyanopiperidine: firstly, cerium(III) chloride heptahydrate (25.5 g, 68.4 mmol) powder was stirred at 145 °C for 18 h under vacuum (<0.1 mmHg). After the solid was cooled to room temperature, THF (120 mL) was added and stirred at room temperature for 2 hours. Subsequently, the suspension was cooled to -78 °C and methyl lithium (45 mL, 1.4 M, dissolved in ether, 63 mmol) was added dropwise over 30 min. The reaction mixture was continued to be stirred at -78 °C for 30 min. A solution of 1-(tert-butoxycarbonyl)-4-cyanopiperidine (4.35 g, 20.7 mmol) in THF (15 mL) was slowly added via cannula, and the reaction was carried out at -78 °C for 4.5 hours. Upon completion of the reaction, ammonium hydroxide (40 mL) was added and the reaction mixture was slowly warmed to room temperature. After addition of dichloromethane (100 mL), the mixture was stirred at room temperature for 1 hour and then filtered through Celite. The Celite pad was washed with dichloromethane (3 x 50 mL). After combining the filtrates, the target product tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate was concentrated under reduced pressure to give tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate (5.0 g, 99% yield).

References

[1] Patent: US2004/10013, 2004, A1. Location in patent: Page/Page column 61

4-(2-Aminopropan-2-yl)-1-Boc-piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-Aminopropan-2-yl)-1-Boc-piperidine Suppliers

China 29 India 1 United States 2 Global 32

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530116-33-7, 4-(2-Aminopropan-2-yl)-1-Boc-piperidineRelated Search:

4-(2-Aminopropan-2-yl)-1-Boc-piperidine

tert-butyl 4-(2-aminopropan-2-yl)piperidine-1-carboxylate

1-Piperidinecarboxylic acid, 4-(1-amino-1-methylethyl)-, 1,1-dimethylethyl ester

1-Boc-4-(2-amino-2-propyl)piperidine

1-Boc-4-(1-amino-1-methylethyl)-piperidine

530116-33-7