Tenapanor hydrochloride
- Product Name
- Tenapanor hydrochloride
- CAS No.
- 1234365-97-9
- Chemical Name
- Tenapanor hydrochloride
- Synonyms
- Tenapanor HCl;Tenapanor 2HCl;RDX5791 hydrochloride;AZD1722 hydrochloride;Tenapanor hydrochloride;Tenapanor dihydrochloride;AZD-1722; AZD 1722; AZD1722; RDX 5791; RDX-5791; RDX5791; TENAPANOR; TENAPANOR HYDROCHLORIDE; TENAPANOR DIHYDROCHLORIDE; IBSRELA.;3-((S)-6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-N-(26-((3-((S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl)sulfonamido)-10,17-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosyl)benzenesulfonamide dihydrochloride;17-[[[3-[(4S)-6,8-Dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]-N-[2-[2-[2-[[[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]phenyl]sulfonyl]amino]ethoxy]ethoxy]ethyl]-8-oxo-12,15-dioxa-2,7,9-triazaheptadecanamide dihydrochloride
- CBNumber
- CB83168756
- Molecular Formula
- C50H68Cl6N8O10S2
- Formula Weight
- 1217.97052
- MOL File
- 1234365-97-9.mol
Tenapanor hydrochloride Property
- storage temp.
- -20°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- color
- White to off-white
- Water Solubility
- Water: soluble
- InChIKey
- VFRAXTZDILCRKY-OWRGXFNZSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
Tenapanor hydrochloride Chemical Properties,Usage,Production
Uses
Tenapanor (AZD1722) HCl is a potent, orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor HCl reduces intestinal phosphate absorption predominantly through the reduction of passive paracellular phosphate flux. Tenapanor HCl has the potential to be used in research on hyperphosphatemia.
Mechanism of action
Tenapanor hydrochloride is a minimally absorbed small molecule sodium/hydrogen exchange isomer 3 (NHE3) inhibitor. NHE3 is involved in the uptake of sodium ions and water into the intestinal lumen, and by inhibiting NHE3, tenapanor is expected to reduce sodium absorption and increase fecal sodium and fluid excretion.
Side effects
Tenapanor hydrochloride is generally well tolerated, with diarrhea being the most common adverse reaction. Diarrhea is usually transient (lasting 1 week) and mild to moderate in severity. Diarrhea develops within a week of starting treatment in approximately half of cases and within the first 3 weeks of treatment in two-thirds of cases. Other possible side effects include abdominal pain, nausea, bloating, and flatulence[1].
Synthesis
Synthesis of Tenapanor hydrochloride
in vivo
Tenapanor hydrochloride (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats[1].
Tenapanor hydrochloride (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats[2].
| Animal Model: | Rats (intestinal loop model)[1] |
| Dosage: | 0.15, 0.5 mg/kg |
| Administration: | P.o. |
| Result: | Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum. |
| Animal Model: | 8 weeks, 250 g male Sprague–Dawley rats[2] |
| Dosage: | 0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt)) |
| Administration: | Oral gavage; twice-daily for 11 consecutive days |
| Result: | Significantly augmented the reduction in urinary phosphorus excretion. |
References
[1] WILLIAM D CHEY. Efficacy of Tenapanor in Treating Patients With Irritable Bowel Syndrome With Constipation: A 26-Week, Placebo-Controlled Phase 3 Trial (T3MPO-2).[J]. American Journal of Gastroenterology, 2021, 116 6: 1294-1303. DOI:10.14309/ajg.0000000000001056.
Tenapanor hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tenapanor hydrochloride manufacturers
- Product
- Tenapanor hydrochloride 1234365-97-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-11-12
- Product
- Tenapanor Hydrochloride 1234365-97-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 50kg/Month
- Release date
- 2024-07-24
- Product
- Tenapanor HCl 1234365-97-9
- Price
- US $0.00/g
- Min. Order
- 10g
- Purity
- 0.99
- Supply Ability
- 1KG
- Release date
- 2024-05-29