ChemicalBook > CAS DataBase List > Seletalisib

Seletalisib

Product Name: Seletalisib
CAS No.: 1362850-20-1
Chemical Name: Seletalisib
Synonyms: UCB5857;Seletalisib;UCB-5857;UCB5857;Seletalisib(UCB-5857);Seletalisib, 10 mM in DMSO;UCB5857; UCB-5857; UCB 5857;Seletalisib (UCB-5857) ，S8560;Inhibitor,Phosphoinositide 3-kinase,Seletalisib,UCB-5857,UCB 5857,inhibit,PI3K;(R)-3-(8-Chloro-3-(2,2,2-trifluoro-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl)quinolin-2-yl)pyridine 1-oxide;Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]-
CBNumber: CB83171699
Molecular Formula: C23H14ClF3N6O
Formula Weight: 482.85
MOL File: 1362850-20-1.mol

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Seletalisib Property

Boiling point:: 710.8±60.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 83.3 mg/mL (172.52 mM)
form: Solid
pka: 3.55±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6470
Product name: Seletalisib
Purity: 98.50%
Packaging: 1mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-6470
Product name: Seletalisib
Purity: 98.50%
Packaging: 5mg
Price: $260
Updated: 2021/12/16

ChemScene

Product number: CS-6470
Product name: Seletalisib
Purity: 98.50%
Packaging: 10mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-6470
Product name: Seletalisib
Purity: 98.50%
Packaging: 50mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-6470
Product name: Seletalisib
Purity: 98.50%
Packaging: 100mg
Price: $2100
Updated: 2021/12/16

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Seletalisib Chemical Properties,Usage,Production

Uses

Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor with an IC50 of 12 nM.

in vivo

Seletalisib significantly inhibits IL-2 release following TCR stimulation in the rat. The inhibition is observed at all tested doses of seletalisib with almost complete inhibition reached at dose levels ≥1 mg/kg. Seletalisib has potent in vivo effects with an estimated IC₅₀ value of <10 nM^[1].

IC 50

PI3Kδ: 12 nM (IC₅₀)

References

[1] Allen RA, et al. Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3Kδ. J Pharmacol Exp Ther. 2017 Apr 25. pii: jpet.116.237347. DOI:10.1124/jpet.116.237347

Seletalisib Preparation Products And Raw materials

Raw materials

Preparation Products

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1362850-20-1, SeletalisibRelated Search:

Seletalisib

UCB5857

Seletalisib(UCB-5857)

UCB5857; UCB-5857; UCB 5857

UCB-5857;UCB5857

Pyrido[3,2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2,2,2-trifluoroethyl]-

Inhibitor,Phosphoinositide 3-kinase,Seletalisib,UCB-5857,UCB 5857,inhibit,PI3K

(R)-3-(8-Chloro-3-(2,2,2-trifluoro-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl)quinolin-2-yl)pyridine 1-oxide

Seletalisib, 10 mM in DMSO

Seletalisib (UCB-5857) ，S8560

1362850-20-1

C23H14ClF3N6O