Gemcitabine monophosphate
- Product Name
- Gemcitabine monophosphate
- CAS No.
- 1638288-31-9
- Chemical Name
- Gemcitabine monophosphate
- Synonyms
- GemMP;Gemcitabine monophosphate disodium;Gemcitabine monophosphate disodium salt;Gemcitabine monophosphate disodium monohydrate;GEMCITABINE MONOPHOSPHATE DISODIUM SALT MONOHYDRATE; GEMCITABINE MONOPHOSPHATE DISODIUM; GEMMP;4-amino-1-((2r,4r,5r)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1h)-one, phosphate salt
- CBNumber
- CB83172757
- Molecular Formula
- C9H13F2N3NaO7P
- Formula Weight
- 367.18
- MOL File
- 1638288-31-9.mol
Gemcitabine monophosphate Property
- storage temp.
- Store at 0-8 °C
- solubility
- DMSO:10.0(Max Conc. mg/mL);24.68(Max Conc. mM)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- DC10590
- Product name
- Gemcitabinemonophosphate
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1350
- Updated
- 2021/12/16
Gemcitabine monophosphate Chemical Properties,Usage,Production
Uses
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles[1][2].
in vivo
Gemcitabine monophosphate (19.5 mg/kg, intravenous injection, every other day, four injections) combined with LCP loaded with VEGF siRNA and GMP shows anti-small cell lung cancer activity and induces apoptosis[1].
| Animal Model: | Subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer[1] |
| Dosage: | 19.5 mg/kg, every other day, four injections |
| Administration: | Intravenous injection (i.v.) |
| Result: | Induced tumor cell apoptosis to 30-40%, reduced tumor cell proliferation by 8 times, significantly reduced tumor microvessel density (MVD), and inhibited tumor mitosis. |
References
[1] Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. DOI:10.1038/mt.2013.120
[2] Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. DOI:10.1002/adfm.201401076
Gemcitabine monophosphate Preparation Products And Raw materials
Raw materials
Preparation Products
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