ChemicalBook > CAS DataBase List > (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE

(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE

Product Name
(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
CAS No.
161230-88-2
Chemical Name
(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
Synonyms
MDL-105212;MDL 105,519;MDL 105,519 >=98% (HPLC), solid;(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE;3-[(1E)-2-Carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
CBNumber
CB8317737
Molecular Formula
C18H11Cl2NO4
Formula Weight
376.19
MOL File
Mol file
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(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE Property

Boiling point:
601.3±55.0 °C(Predicted)
Density 
1.594±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/mL
pka
3.20±0.19(Predicted)
form 
solid
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M216
Product name
MDL 105,519
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$653.6
Updated
2025/07/31
Sigma-Aldrich
Product number
M216
Product name
MDL 105,519
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$2760
Updated
2025/07/31
ChemScene
Product number
CS-3882
Product name
MDL 105,519
Purity
97.15%
Packaging
5mg
Price
$420
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC65085
Product name
MDL 105519
Packaging
50mg
Price
$438
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0142066
Product name
(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)ENE
Purity
95.00%
Packaging
5MG
Price
$501.31
Updated
2021/12/16
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(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE Chemical Properties,Usage,Production

Uses

MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor.

Biochem/physiol Actions

MDL 105,519 is a high affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist at the glycine site. It inhibits NMDA-dependent responses.

in vivo

MDL 105519 is an NMDA receptor antagonistin vivo. Intravenously administration of MDL 105519 prevents harmaline-stimulated increases in cerebellar cyclic GMP content, providing biochemical evidence of NMDA receptor antagonism in vivo. This antagonism is associated with anticonvulsant activity in genetically based, chemically induced, and electrically mediated seizure models. Anxiolytic activity is observed in the rat separation-induced vocalization model, but muscle-relaxant activity is apparent at lower doses. Higher doses impair rotorod performance, but are without effect on mesolimbic dopamine turnover or prepulse inhibition of the startle reflex[1].

IC 50

NMDA Receptor

References

[1] Baron BM, et al. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997 Apr 4;323(2-3):181-92. DOI:10.1016/s0014-2999(97)00045-9

(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE Suppliers

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161230-88-2, (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENERelated Search:

3-METHYLSTYRENE CHOLESTEROL ESTERASE 4,6-Dichloro-1H-indole

  • MDL-105212
  • MDL 105,519
  • 3-[(1E)-2-Carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid
  • (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
  • 1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
  • MDL 105,519 >=98% (HPLC), solid
  • 161230-88-2
  • C18H11Cl2NO4