Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

Product Name: Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
CAS No.: 5184-64-5
Chemical Name: Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
Synonyms: ESI-05;NSC 116966;ESI-05 (ESI05);ESI-05 (NSC 116966);ESI-05 >=98% (HPLC);ESI-05, 10 mM in DMSO;MESITYL P-TOLYL SULFONE;1,3,5-trimethyl-2-tosylbenzene;1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene;Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-
CBNumber: CB83290819
Molecular Formula: C16H18O2S
Formula Weight: 274.38
MOL File: 5184-64-5.mol

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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Property

Melting point:: 119-120 °C
Boiling point:: 426.7±45.0 °C(Predicted)
Density: 1.129±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1907
Product name: ESI-05
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1907
Product name: ESI-05
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $424
Updated: 2024/03/01

Sigma-Aldrich

Product number: S798975
Product name: MESITYL P-TOLYL SULFONE
Purity: AldrichCPR
Packaging: 50MG
Price: $179
Updated: 2024/03/01

Cayman Chemical

Product number: 29702
Product name: ESI-05
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29702
Product name: ESI-05
Packaging: 25mg
Price: $343
Updated: 2024/03/01

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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Chemical Properties,Usage,Production

Uses

ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury.

Biochem/physiol Actions

ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants.

storage

Store at RT

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- Suppliers

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5184-64-5, Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-Related Search:

Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-

1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene

MESITYL P-TOLYL SULFONE

ESI-05

ESI-05 (ESI05)

1,3,5-trimethyl-2-tosylbenzene

NSC 116966

ESI-05 >=98% (HPLC)

ESI-05 (NSC 116966)

Diacylglycerol acyltransferase,diabetes,Inhibitor,inhibit,Intracranial hemorrhage (ICH),Acyltransferase,cAMP,acyl-CoA:cholesterol acyltransferase,NSC116966,insulin secretion,mono- acylglycerol acyltransferase,exchange proteins directly activated by cAMP 2 (EPAC2),neurological disorders,NSC-116966,GEF,Diglyceride acyltransferase,ESI 05,ESI-05,ESI05

ESI-05, 10 mM in DMSO

5184-64-5