ChemicalBook > CAS DataBase List > SPI 112

SPI 112

Product Name: SPI 112
CAS No.: 1051387-90-6
Chemical Name: SPI 112
Synonyms: SPI 112;SPI-112;SPI112;SPI-112 ，S0244;SPI-112, 10 mM in DMSO;(Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid;(z)-3-(2-(5-(n-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazineyl)benzoic acid;SPR,SPI 112,Phosphatase,inhibit,SHP2,Inhibitor,PTP1B,anticancer,PTP,PTPN11,competitive,SPI112,SPI-112;Benzoic acid, 3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-
CBNumber: CB83303342
Molecular Formula: C22H17FN4O5S
Formula Weight: 468.46
MOL File: 1051387-90-6.mol

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SPI 112 Property

Melting point:: >300 °C
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMF: 1 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
form: A crystalline solid
pka: 4.15±0.10(Predicted)
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29474
Product name: SPI 112
Packaging: 100mg
Price: $434
Updated: 2024/03/01

Cayman Chemical

Product number: 29474
Product name: SPI 112
Packaging: 250mg
Price: $765
Updated: 2024/03/01

Cayman Chemical

Product number: 29474
Product name: SPI 112
Packaging: 25mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 29474
Product name: SPI 112
Packaging: 50mg
Price: $243
Updated: 2024/03/01

AK Scientific

Product number: 6461EM
Product name: 3-[[5-[(4-Fluorophenyl)methylsulfamoyl]-2-hydroxy-1H-indol-3-yl]diazenyl]benzoicacid
Packaging: 50mg
Price: $370
Updated: 2021/12/16

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SPI 112 Chemical Properties,Usage,Production

Uses

SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2].

References

[1] Chen L, et al. Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112. Biochem Pharmacol. 2010 Sep 15;80(6):801-10. DOI:10.1016/j.bcp.2010.05.019
[2] Lawrence HR, et al. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem. 2008 Aug 28;51(16):4948-56. DOI:10.1021/jm8002526

SPI 112 Preparation Products And Raw materials

Raw materials

Preparation Products

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1051387-90-6, SPI 112Related Search:

SPI 112

SPI-112;SPI112

Benzoic acid, 3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-

(Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid

SPR,SPI 112,Phosphatase,inhibit,SHP2,Inhibitor,PTP1B,anticancer,PTP,PTPN11,competitive,SPI112,SPI-112

SPI-112, 10 mM in DMSO

SPI-112 ，S0244

(z)-3-(2-(5-(n-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazineyl)benzoic acid

1051387-90-6

C22H17FN4O5S