ChemicalBook > CAS DataBase List > AU1235
AU1235
- Product Name
- AU1235
- CAS No.
- 1338780-86-1
- Chemical Name
- AU1235
- Synonyms
- AU1235;AU1235, 10 mM in DMSO;AU1235;AU-1235;AU 1235;1-(Adamantan-1-yl)-3-(2,3,4-trifluorophenyl)urea;Urea, N-tricyclo[3.3.1.13,7]dec-1-yl-N'-(2,3,4-trifluorophenyl)-;Inhibitor,MmpL3,transport,tuberculosis,AU1235,cell,AU 1235,AU-1235,synthesis,inhibit,Bacterial,wall,Mycobacterium
- CBNumber
- CB83309531
- Molecular Formula
- C17H19F3N2O
- Formula Weight
- 324.34
- MOL File
- 1338780-86-1.mol
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AU1235 Property
- Boiling point:
- 377.7±42.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 6 mg/mL (18.50 mM)
- pka
- 12.02±0.70(Predicted)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-6863
- Product name
- AU1235
- Purity
- 99.18%
- Packaging
- 2mg
- Price
- $132
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6863
- Product name
- AU1235
- Purity
- 99.18%
- Packaging
- 5mg
- Price
- $264
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6863
- Product name
- AU1235
- Purity
- 99.18%
- Packaging
- 10mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6863
- Product name
- AU1235
- Purity
- 99.18%
- Packaging
- 25mg
- Price
- $900
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-6863
- Product name
- AU1235
- Purity
- 99.18%
- Packaging
- 50mg
- Price
- $1440
- Updated
- 2021/12/16
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AU1235 Chemical Properties,Usage,Production
Uses
AU1235, an adamantyl urea, is a potent MmpL3 inhibitor. The Mycobacterium tuberculosis protein MmpL3 performs an essential role in cell wall synthesis, since it effects the transport of trehalose monomycolates across the inner membrane[1][2].
References
[1] McNeil MB, et al. Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. mSphere. 2020;5(5):e00985-20. Published 2020 Oct 14. DOI:10.1128/mSphere.00985-20
[2] Grzegorzewicz AE, et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol. 2012;8(4):334-341. Published 2012 Feb 19. DOI:10.1038/nchembio.794
AU1235 Preparation Products And Raw materials
Raw materials
Preparation Products
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