R162

Product Name: R162
CAS No.: 64302-87-0
Chemical Name: R162
Synonyms: R162, >98%;R162;R-162;R 162;R162,inhibit,R-162,Inhibitor,R 162;2-Allyl-1-hydroxy-9,10-anthraquinone;9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-
CBNumber: CB83334050
Molecular Formula: C17H12O3
Formula Weight: 264.28
MOL File: 64302-87-0.mol

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R162 Property

Melting point:: 120-120.5 °C(Solv: acetone (67-64-1))
Boiling point:: 459.0±34.0 °C(Predicted)
Density: 1.308±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml)
form: solid
pka: 7.43±0.20(Predicted)
color: Orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

DC Chemicals

Product number: DC10692
Product name: R162
Purity: >98%
Packaging: 100mg
Price: $500
Updated: 2021/12/16

DC Chemicals

Product number: DC10692
Product name: R162
Purity: >98%
Packaging: 250mg
Price: $1000
Updated: 2021/12/16

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R162 Chemical Properties,Usage,Production

Description

R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki?= 28.6 μM).? It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment leads to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells.? R162 sensitizes LKB-1 deficient tumor cells to anoikis induction.? R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2? GDH1 is a promising antimetastasis target and R162 is a useful tool for proof of principal studies.

Uses

R162 is a glutamate dehydrogenase 1 inhibitor for the treatment of cancer. A useful bioactive chemical compound.

Definition

ChEBI: 2-allyl-1-hydroxy-9,10-anthraquinone is a monohydroxyanthraquinone that is 9,10-anthraquinone in which the hydrogens at positions 1 and 2 are replaced by a hydroxy and an allyl group, respectively. It has a role as an EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitor.

References

1) Jin?et al. (2015),?Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth; Cancer Cell,?27?257 2) Jin?et al.?(2018)?The PLAG1-GDH1 Axis Promotes Anokis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer; Mol. Cell,?69?1

R162 Preparation Products And Raw materials

Raw materials

Preparation Products

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R162 Suppliers

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64302-87-0, R162Related Search:

ZM 447439 CYCLOPAMINE Cantharidin Brefeldin A

R162;R-162;R 162

R162, >98%

2-Allyl-1-hydroxy-9,10-anthraquinone

9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-

R162,inhibit,R-162,Inhibitor,R 162

64302-87-0