R162
- Product Name
- R162
- CAS No.
- 64302-87-0
- Chemical Name
- R162
- Synonyms
- R162, >98%;R162;R-162;R 162;R162, 10 mM in DMSO;GDH1 Inhibitor, R162;2-ALLYL-1-HYDROXY-ANTHRAQUINONE;R162,inhibit,R-162,Inhibitor,R 162;2-Allyl-1-hydroxy-9,10-anthraquinone;2-allyl-1-hydroxyanthracene-9,10-dione;9,10-Anthracenedione, 1-hydroxy-2-(2-propenyl)-;9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)-
- CBNumber
- CB83334050
- Molecular Formula
- C17H12O3
- Formula Weight
- 264.28
- MOL File
- 64302-87-0.mol
R162 Property
- Melting point:
- 120-120.5 °C(Solv: acetone (67-64-1))
- Boiling point:
- 459.0±34.0 °C(Predicted)
- Density
- 1.308±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml or in Ethanol (up to 5 mg/ml)
- form
- solid
- pka
- 7.43±0.20(Predicted)
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 5.38098
- Product name
- GDH1 Inhibitor, R162
- Packaging
- 25 mg
- Price
- $206
- Updated
- 2025/07/31
- Product number
- DC10692
- Product name
- R162
- Purity
- >98%
- Packaging
- 100mg
- Price
- $500
- Updated
- 2021/12/16
- Product number
- DC10692
- Product name
- R162
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1000
- Updated
- 2021/12/16
R162 Chemical Properties,Usage,Production
Description
R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki?= 28.6 μM).? It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment leads to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells.? R162 sensitizes LKB-1 deficient tumor cells to anoikis induction.? R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2? GDH1 is a promising antimetastasis target and R162 is a useful tool for proof of principal studies.
Uses
R162 is a glutamate dehydrogenase 1 inhibitor for the treatment of cancer. A useful bioactive chemical compound.
Definition
ChEBI: 2-allyl-1-hydroxy-9,10-anthraquinone is a monohydroxyanthraquinone that is 9,10-anthraquinone in which the hydrogens at positions 1 and 2 are replaced by a hydroxy and an allyl group, respectively. It has a role as an EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitor.
in vivo
R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice[1].
References
[1] LINGTAO JIN. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.[J]. Cancer Cell, 2015, 27 2: 257-270. DOI:10.1016/j.ccell.2014.12.006
[2] LINGTAO JIN. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer.[J]. Molecular Cell, 2018, 69 1: 87-99.e7. DOI:10.1016/j.molcel.2017.11.025
R162 Preparation Products And Raw materials
Raw materials
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