ChemicalBook > CAS DataBase List > MAK-683

MAK-683

Product Name
MAK-683
CAS No.
1951408-58-4
Chemical Name
MAK-683
Synonyms
MAK-683;CPD 1111;EED inhibitor-1;MAK 683;MAK-683;MAK683;MAK683,EED inhibitor-1;inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683;N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID;N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine;N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine;1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-
CBNumber
CB83334085
Molecular Formula
C20H17FN6O
Formula Weight
376.39
MOL File
1951408-58-4.mol
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MAK-683 Property

Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 15 mg/ml
form 
A solid
pka
2.70±0.12(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29316
Product name
MAK-683
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
29316
Product name
MAK-683
Packaging
10mg
Price
$593
Updated
2024/03/01
Cayman Chemical
Product number
29316
Product name
MAK-683
Packaging
5mg
Price
$336
Updated
2024/03/01
TRC
Product number
M198120
Product name
MAK-683
Packaging
1mg
Price
$85
Updated
2021/12/16
ChemScene
Product number
CS-8054
Product name
MAK683
Purity
98.05%
Packaging
5mg
Price
$130
Updated
2021/12/16
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MAK-683 Chemical Properties,Usage,Production

Description

MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.

Uses

MAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1.

MAK-683 Preparation Products And Raw materials

Raw materials

Preparation Products

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MAK-683 Suppliers

China 56 United States 7 Global 63
ShangHai Caerulum Pharma Discovery Co., Ltd.
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ATK CHEMICAL COMPANY LIMITED
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1951408-58-4, MAK-683Related Search:


  • CPD 1111
  • MAK-683
  • EED inhibitor-1
  • MAK 683;MAK-683;MAK683
  • N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
  • N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID
  • 1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-
  • inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683
  • MAK683,EED inhibitor-1
  • N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
  • 1951408-58-4