ChemicalBook > CAS DataBase List > MAK-683

MAK-683

Product Name: MAK-683
CAS No.: 1951408-58-4
Chemical Name: MAK-683
Synonyms: MAK-683;CPD 1111;EED inhibitor-1;MAK683 (MAK-683;MAK683, 10 mM in DMSO;MAK 683;MAK-683;MAK683;MAK683,EED inhibitor-1;inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683;N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID;N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CBNumber: CB83334085
Molecular Formula: C20H17FN6O
Formula Weight: 376.39
MOL File: 1951408-58-4.mol

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MAK-683 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 15 mg/ml
form: A solid
pka: 2.70±0.12(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29316
Product name: MAK-683
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 29316
Product name: MAK-683
Packaging: 10mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 29316
Product name: MAK-683
Packaging: 5mg
Price: $336
Updated: 2024/03/01

TRC

Product number: M198120
Product name: MAK-683
Packaging: 1mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-8054
Product name: MAK683
Purity: 98.05%
Packaging: 5mg
Price: $130
Updated: 2021/12/16

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MAK-683 Chemical Properties,Usage,Production

Description

MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC₅₀ value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC₅₀ = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC₅₀ value of 3 nM.

Uses

MAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1.

References

[1] 4910194 Thienotriazolodiazepine compounds and pharmaceutical uses thereof[J]. General Pharmacology-the Vascular System, 1990, 21 6: Pages xi-xii. DOI: 10.1016/0306-3623(90)90536-u

MAK-683 Preparation Products And Raw materials

Raw materials

Preparation Products

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1951408-58-4, MAK-683Related Search:

CPD 1111

MAK-683

EED inhibitor-1

MAK 683;MAK-683;MAK683

N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine

N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID

1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-

inhibit,MAK683,MAK-683,Inhibitor,Histone Methyltransferase,MAK 683

MAK683,EED inhibitor-1

N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

MAK683, 10 mM in DMSO

MAK683 (MAK-683

1951408-58-4