3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine
- Product Name
- 3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine
- CAS No.
- 2095417-76-6
- Chemical Name
- 3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine
- Synonyms
- 3'-Azido-3'-deoxy-5-fluoro-b-L-cytidine;3’-Azido-3’-deoxy-5-fluoro-β-L-cytidine;3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine;3’-Azido-3’-deoxy-5-fluoro-beta-L-cytidine;4-amino-1-((2S,3S,4R,5R)-4-azido-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoropyrimidin-2(1H)-one
- CBNumber
- CB83334232
- Molecular Formula
- C9H11FN6O4
- Formula Weight
- 286.22
- MOL File
- 2095417-76-6.mol
3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine Chemical Properties,Usage,Production
Uses
3’-Azido-3’-deoxy-5-fluoro-beta-L-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-5-fluoro-beta-L-cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
3'-Azido-3'-deoxy-5-fluoro-beta-L-cytidine Preparation Products And Raw materials
Raw materials
Preparation Products
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