5-Bromo-4-methyl-2-(methylthio)pyrimidine
Uses Application- Product Name
- 5-Bromo-4-methyl-2-(methylthio)pyrimidine
- CAS No.
- 1294446-69-7
- Chemical Name
- 5-Bromo-4-methyl-2-(methylthio)pyrimidine
- Synonyms
- 5-Bromo-4-methyl-2-(methylthio)pyrimidine;5-bromo-4-methyl-2-methylsulfanylpyrimidine;Pyrimidine, 5-bromo-4-methyl-2-(methylthio)-
- CBNumber
- CB83334863
- Molecular Formula
- C6H7BrN2S
- Formula Weight
- 219.1
- MOL File
- 1294446-69-7.mol
5-Bromo-4-methyl-2-(methylthio)pyrimidine Property
- Boiling point:
- 297.9±20.0 °C(Predicted)
- Density
- 1.62±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.07±0.29(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B681403
- Product name
- 5-Bromo-4-Methyl-2-(methylthio)pyrimidine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 8399DN
- Product name
- 5-Bromo-4-methyl-2-(methylthio)pyrimidine
- Packaging
- 250mg
- Price
- $107
- Updated
- 2021/12/16
- Product number
- CM248721
- Product name
- 5-Bromo-4-methyl-2-(methylthio)pyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- CD11298609
- Product name
- 5-Bromo-4-methyl-2-(methylthio)pyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- A111073
- Product name
- 5-Bromo-4-methyl-2-(methylthio)pyrimidine
- Purity
- 95%
- Packaging
- 5g
- Price
- $400
- Updated
- 2021/12/16
5-Bromo-4-methyl-2-(methylthio)pyrimidine Chemical Properties,Usage,Production
Uses
5-Bromo-4-methyl-2-(methylthio)pyrimidine can be used as a pharmaceutical synthesis intermediate. It can be prepared by nucleophilic substitution reaction of 5-bromo-4-methyl-2-chloropyrimidine with sodium methanethiol.
Application
5-Bromo-4-methyl-2-(methylthio)pyrimidine can be used to prepare pyrazole derivatives having the following structure, which can act as inhibitors of cyclin-dependent kinases. These compounds, their intermediates, and pharmaceutical compositions comprising these compounds can be used to treat diseases related to protein kinase disorders. This invention also reports these compounds or compositions thereof as modulators of Jak1, Jak2, and Jak3, as well as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, and CDK9. This invention also relates to methods of combination therapy, which apply the compounds or pharmaceutical compositions of this invention or their kits to inhibit protein kinase activity in cells or to treat, prevent, or improve one or more symptoms of cancer, transplant rejection, and autoimmune diseases in patients.
5-Bromo-4-methyl-2-(methylthio)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromo-4-methyl-2-(methylthio)pyrimidine Suppliers
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