2-Hydroxybenzophenone Property

Melting point:

37-39 °C (lit.)

Boiling point:

171-173 °C/12 mmHg (lit.)

Density 

1.1184 (rough estimate)

refractive index 

1.5954 (estimate)

Flash point:

>230 °F

storage temp. 

Sealed in dry,2-8°C

pka

8.07±0.30(Predicted)

form 

Crystalline Powder

color 

Yellow

Water Solubility 

insoluble

BRN 

1638174

CAS DataBase Reference

117-99-7(CAS DataBase Reference)

NIST Chemistry Reference

Methanone, (2-hydroxyphenyl)phenyl-(117-99-7)

EPA Substance Registry System

Methanone, (2-hydroxyphenyl)phenyl- (117-99-7)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29145000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

2-Hydroxybenzophenone Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

UV absorber in plastics.

Uses

2-Hydroxybenzophenone was used to quantify the metabolites of unmethylated extracts from the supernatants of Pseudomonas acidovorans cultures grown on 1,1-diphenylethylene.

Application

2-Hydroxybenzophenone was used to quantify the metabolites of unmethylated extracts from the supernatants of Pseudomonas acidovorans cultures grown on 1,1-diphenylethylene.
2-Hydroxybenzophenone forms copolymer 2-hydroxy, 3-allyl, 4,4′-dimethoxybenzophenone with methyl methacrylate.
It forms photostabilizer compounds with 2,2,6,6-tetramethylpiperidine under phase transfer catalysis conditions.
It reacts with 3-aminophenyl boronic acid to form macrocyclic boronates.

Preparation

Preparation by Friedel–Crafts acylation of benzene in the presence of aluminium chloride,
? with 2-hydroxybenzoyl chloride (salicylic acid chloride), (52%), (39%), at temperature <60°;
? with o-anisoyl chloride. Demethylation occurred during the Friedel–Crafts acylation, especially in the presence of ferric chloride at 130–140°;
? with 2-ethoxybenzoyl chloride in a boiling water bath (42%).

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 5469, 1954 DOI: 10.1021/ja01650a062
The Journal of Organic Chemistry, 32, p. 3844, 1967 DOI: 10.1021/jo01287a027

General Description

• 2-Hydroxybenzophenone forms copolymer 2-hydroxy, 3-allyl, 4,4′-dimethoxybenzophenone with methyl methacrylate.
• It forms photostabilizer compounds with 2,2,6,6-tetramethylpiperidine under phase transfer catalysis conditions.
• It reacts with 3-aminophenyl boronic acid to form macrocyclic boronates.