5-METHYL-THIAZOLE-4-CARBOXYLIC ACID
- Product Name
- 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID
- CAS No.
- 61323-26-0
- Chemical Name
- 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID
- Synonyms
- 5-methylthiazole-4-ethyl formate;4-Ethoxycarbonyl-5-methylthiazole;Ethyl 5-methylthiazol-4-carboxylate;5-METHYL-THIAZOLE-4-CARBOXYLIC ACID;ETHYL 5-METHYLTHIAZOLE-4-CARBOXYLATE;Ethyl 5-methyl-4-thiazolecarboxylate;Ethyl 5-Methylthiazloe-4-carboxylate;ethyl 5-Methyl-1,3-thiazole-4-carboxylate;5-Methyl-thiazole-4-carboxylic acid ethyl ester;4-Thiazolecarboxylicacid, 5-methyl-, ethyl ester
- CBNumber
- CB8333896
- Molecular Formula
- C7H9NO2S
- Formula Weight
- 171.22
- MOL File
- Mol file
5-METHYL-THIAZOLE-4-CARBOXYLIC ACID Property
- Melting point:
- 90-91℃
- Boiling point:
- 239℃
- Density
- 1.198
- Flash point:
- 98℃
- storage temp.
- 2-8°C
- form
- solid
- pka
- 0.86±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- 1S/C5H5NO2S/c1-3-4(5(7)8)6-2-9-3/h2H,1H3,(H,7,8)
- InChIKey
- OIWNDJQQIMISPC-UHFFFAOYSA-N
- SMILES
- Cc1scnc1C(O)=O
Safety
- WGK Germany
- WGK 3
- HS Code
- 2934999090
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E936925
- Product name
- Ethyl5-Methylthiazole-4-carboxylate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 284617
- Product name
- 5-Methyl-Thiazole-4-carboxylic acid
- Packaging
- 250mg
- Price
- $358
- Updated
- 2021/12/16
- Product number
- P000223035
- Product name
- Ethyl 5-methylthiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $408
- Updated
- 2021/12/16
- Product number
- P000223035
- Product name
- Ethyl 5-methylthiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
- Product number
- 069958
- Product name
- 5-Methylthiazole-4-carboxylic acid ethyl ester
- Purity
- 96%
- Packaging
- 1g
- Price
- $227
- Updated
- 2021/12/16
5-METHYL-THIAZOLE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
pale yellow solid
Synthesis
72054-60-5
61323-26-0
General procedure for the synthesis of ethyl 5-methylthiazole-4-carboxylate from ethyl 2-amino-5-methylthiazole-4-carboxylate: ethyl 2-amino-5-methylthiazole-4-carboxylate (62.9 g, 338 mmol) was mixed with tetrahydrofuran (THF, 630 mL) in a three-necked round-bottomed flask equipped with a stirrer. The reaction mixture was heated to reflux followed by slow dropwise addition of isoamyl cyanide (52.6 g, 60.1 mL, 449 mmol). After the dropwise addition was completed, the reaction mixture was continued to be stirred under reflux conditions for 1 hour. Upon completion of the reaction, the reaction mixture was concentrated using a rotary evaporator (under high vacuum) to give 70 g of crude product, which appeared as a thick orange oil. Purification of the crude product by silica gel column chromatography (silica gel 400 g, eluent 20-45% ethyl acetate/hexane) gave 39.47 g (68% yield) of ethyl 5-methylthiazole-4-carboxylate as a yellow solid. It was analyzed by liquid chromatography-electrospray mass spectrometry (LC-ES/MS) and m/z 172 ([M+1]+) was measured with a retention time (TR) of 1.5 min.
References
[1] Patent: US2010/69404, 2010, A1. Location in patent: Page/Page column 16
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982, p. 159 - 164
5-METHYL-THIAZOLE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID manufacturers
- Product
- 5-METHYL-THIAZOLE-4-CARBOXYLIC ACID 61323-26-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24