ChemicalBook > CAS DataBase List > 4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-

4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-

Product Name
4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-
CAS No.
139652-01-0
Chemical Name
4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-
Synonyms
Sigma-LIGAND-1;SigmaLIGAND1,Sigma LIGAND 1;Sigma-LIGAND-1, 10 mM in DMSO;4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-
CBNumber
CB83339585
Molecular Formula
C27H33NO4
Formula Weight
435.55522
MOL File
139652-01-0.mol
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4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl- Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl- Chemical Properties,Usage,Production

Uses

Sigma-LIGAND-1 is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000 nM at the dopamine D2 receptor[1].

in vivo

Administration of Sigma-LIGAND-1 would reverse amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 and its structural analogues have the potential antipsychotic activity[1].

References

[1] Erickson RH, et al. (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem. 1992 May 1;35(9):1526-35. DOI:10.1021/jm00087a005

4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl- Suppliers

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139652-01-0, 4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-Related Search:


  • 4H-1-Benzopyran-4-one, 6-[[6-(4-hydroxy-1-piperidinyl)hexyl]oxy]-3-methyl-2-phenyl-
  • Sigma-LIGAND-1
  • SigmaLIGAND1,Sigma LIGAND 1
  • Sigma-LIGAND-1, 10 mM in DMSO
  • 139652-01-0