ChemicalBook > CAS DataBase List > BCI-121

BCI-121

Product Name
BCI-121
CAS No.
432529-82-3
Chemical Name
BCI-121
Synonyms
BCL 121;BCI-121;BCI-121;BCI 121;BCI121;1-Piperidineacetamide, 4-(aminocarbonyl)-N-(4-bromophenyl)-;1-{2-[(4-bromophenyl)amino]-2-oxoethyl}piperidine-4-carboxamide;inhibit,BCI 121,Histone Methyltransferase,Inhibitor,BCI-121,BCI121
CBNumber
CB83339611
Molecular Formula
C14H18BrN3O2
Formula Weight
340.22
MOL File
432529-82-3.mol
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BCI-121 Property

Boiling point:
576.1±50.0 °C(Predicted)
Density 
1.474±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF:30.0(Max Conc. mg/mL);88.18(Max Conc. mM)
DMSO:66.0(Max Conc. mg/mL);193.99(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.97(Max Conc. mM)
Ethanol:39.0(Max Conc. mg/mL);114.63(Max Conc. mM)
pka
13.82±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1817
Product name
BCI-121
Purity
≥98% (HPLC)
Packaging
5mg
Price
$114
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1817
Product name
BCI-121
Purity
≥98% (HPLC)
Packaging
25mg
Price
$464
Updated
2024/03/01
ChemScene
Product number
CS-B1554
Product name
BCI-121
Purity
99.45%
Packaging
5mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-B1554
Product name
BCI-121
Purity
99.45%
Packaging
10mg
Price
$114
Updated
2021/12/16
ChemScene
Product number
CS-B1554
Product name
BCI-121
Purity
99.45%
Packaging
25mg
Price
$234
Updated
2021/12/16
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BCI-121 Chemical Properties,Usage,Production

Biochem/physiol Actions

BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level (by 50%/H3K4me2 and 40%H3K4me3 in HT29 cells; 100 μM BCI-121 for 48 h), downregulates known SMYD3 target genes transcription, and selectively affects SMYD3-dependent proliferation of cancer cultures (46%/HT29 and 54%/HCT116 proliferation reduction; 100 μM BCI-121 for 72 h) with little antiproliferation efficacy toward low SMYD3-expressing cancer cells. BCI-121 targets SMYD3 via direct affinity interaction (kon 357.7/M/s; koff 4.23×10-3/s; KD=koff/kon = 11.8 μM) and effectively competes against histone for SMYD3 binding (%inhibition/[histone H4 peptide]:[BCI-121] ratio = 36.5%/1:1 and 51.0%/1:2.5).

BCI-121 Preparation Products And Raw materials

Raw materials

Preparation Products

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BCI-121 Suppliers

China 42 United States 8 Global 50
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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432529-82-3, BCI-121Related Search:


  • BCI-121;BCI 121;BCI121
  • BCI-121
  • 1-{2-[(4-bromophenyl)amino]-2-oxoethyl}piperidine-4-carboxamide
  • 1-Piperidineacetamide, 4-(aminocarbonyl)-N-(4-bromophenyl)-
  • BCL 121
  • inhibit,BCI 121,Histone Methyltransferase,Inhibitor,BCI-121,BCI121
  • 432529-82-3