KP496

Product Name: KP496
CAS No.: 217799-03-6
Chemical Name: KP496
Synonyms: KP496;KP496,KP-496;Benzoic acid, 2-[[[4-[[(4-chlorophenyl)sulfonyl]amino]butyl][[3-[[4-(1-methylethyl)-2-thiazolyl]methoxy]phenyl]methyl]amino]sulfonyl]-
CBNumber: CB83339666
Molecular Formula: C31H34ClN3O7S3
Formula Weight: 692.27
MOL File: 217799-03-6.mol

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KP496 Property

Boiling point:: 847.9±75.0 °C(Predicted)
Density: 1.378±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 3.09±0.36(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-7445
Product name: KP496
Purity: 95.81%
Packaging: 5mg
Price: $2650
Updated: 2021/12/16

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KP496 Chemical Properties,Usage,Production

Uses

KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.

in vivo

KP496 significantly inhibits acute (day 7) and chronic (day 21) lung inflammation. KP496 attenuates the number of lymphocytes on day 7 and those of macrophages, neutrophils, and eosinophils on days 7 and 21. KP496 and prednisolone significantly suppress the increase of hydroxyl-L-proline content in the lung. Compare to respective vehicle control group, the inhibition ratio of KP496 and prednisolone for increase of hydroxyl-L-proline content is about 74 and 63%, respectively^[1]. The KP496 (100 mg/head) group and prednisolone (10 mg/kg) group exhibit significant inhibition of numbers of infiltrating total cells, eosinophils, monocytes/macrophages, and lymphocytes compare with the control group. Infiltration of all types of cells except neutrophils is decreased in the KP496 (30m g/head) group, though not to significant extents^[2].

IC 50

LTD₄; TXA₂ Receptor

References

[1] Kurokawa S, et al. Effect of inhaled KP-496, a novel dual antagonist of the cysteinyl leukotriene and thromboxane A2 receptors, on a bleomycin-induced pulmonary fibrosis model in mice. Pulm Pharmacol Ther. 2010 Oct;23(5):425-31. DOI:10.1016/j.pupt.2010.04.008
[2] Ishimura M, et al. Effects of KP-496, a novel dual antagonist for cysteinyl leukotriene receptor 1 and thromboxane A2 receptor, on Sephadex-induced airway inflammation in rats. Biol Pharm Bull. 2009 Jun;32(6):1057-61. DOI:10.1248/bpb.32.1057

KP496 Preparation Products And Raw materials

Raw materials

Preparation Products

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KP496 Suppliers

China 4 United States 6 Global 10

MedChemexpress LLC

Tel: 021-58955995
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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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TargetMol Chemicals Inc.

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Suzhou Meishi Biotechnology Co., Ltd.

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Biosynth Biological Technology (Suzhou) Co Ltd

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TargetMol Chemicals Inc.

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Country: United States
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TargetMol Chemicals Inc.

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Aladdin Scientific

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217799-03-6, KP496Related Search:

KP496

Benzoic acid, 2-[[[4-[[(4-chlorophenyl)sulfonyl]amino]butyl][[3-[[4-(1-methylethyl)-2-thiazolyl]methoxy]phenyl]methyl]amino]sulfonyl]-

KP496,KP-496

217799-03-6

C31H34ClN3O7S3