Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-

Product Name: Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
CAS No.: 169474-77-5
Chemical Name: Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
Synonyms: FCE 28654;Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-
CBNumber: CB83339727
Molecular Formula: C25H35N2O7P
Formula Weight: 506.53
MOL File: 169474-77-5.mol

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Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]- Property

Density: 1.242±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 1.22±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

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Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]- Chemical Properties,Usage,Production

Uses

FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69 μM, respcetively.

in vivo

FCE 28654 (15 mg/kg, p.o.) dramatically decreases blood cholesterol and modifies the hepatic cholesterol pattern via enhancing the free/esterified cholesterol ratio, in hypercholesterolemic rats. FCE 28654 (100 mg/kg, p.o.) also reduces microsomal ACAT activity rat plasma^[1].

References

[1] A.Chiari, et al. Synthesis and pharmacological profile of FCE 28654: A water-soluble and injectable ACAT inhibitor. Bioorganic & Medicinal Chemistry Letters. 1995 Aug 3;5(15):1581-1586.

Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]- Suppliers

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169474-77-5, Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-Related Search:

Urea, N-[2,6-bis(1-methylethyl)phenyl]-N'-[[(4R,5R)-4,5-dimethyl-2-[4-(phosphonooxy)phenyl]-1,3-dioxolan-2-yl]methyl]-

FCE 28654

169474-77-5