(-)BI97D6

Product Name: (-)BI97D6
CAS No.: 1430067-36-9
Chemical Name: (-)BI97D6
Synonyms: (-)BI97D6;[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(phenylmethyl)-, (-)-
CBNumber: CB83339752
Molecular Formula: C36H26O8
Formula Weight: 586.59
MOL File: 1430067-36-9.mol

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(-)BI97D6 Property

Boiling point:: 892.2±65.0 °C(Predicted)
Density: 1.454±0.06 g/cm3(Predicted)
pka: 6.23±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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(-)BI97D6 Chemical Properties,Usage,Production

Uses

(-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values ??of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells[1].

IC 50

Bcl-xL: 0.076 μM (IC₅₀); Mcl-1: 0.025 μM (IC₅₀); Bcl-2: 0.031 μM (IC₅₀); Bcl-1: 0.122 μM (IC₅₀)

References

[1] Rongqing Pan, et al. "Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–) BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia." Blood, The Journal of the American Society of Hematology 126.3 (2015): 363-372. DOI:10.1182/blood-2014-10-604975

(-)BI97D6 Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)BI97D6 Suppliers

China 2 Global 2

TargetMol Chemicals Inc.

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Email: marketing@targetmol.cn
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ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

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1430067-36-9, (-)BI97D6Related Search:

(-)BI97D6

[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(phenylmethyl)-, (-)-

1430067-36-9