ChemicalBook > CAS DataBase List > AMG176

AMG176

Product Name: AMG176
CAS No.: 1883727-34-1
Chemical Name: AMG176
Synonyms: AMG176;CS-2836;Tapotoclax;AMG-176 (TAPOTOCLAX);Tapotoclax（ AMG-176）;Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-, 10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-;(1S,11'R,12'S,16'S,16a'R,18a'R,E)-6-Chloro-16'-methoxy-11',12'-dimethyl-3,4,12',13',16',16a',17',18',18a',19'-decahydro-1'H,2H,3'H,11'H-spiro[naphthalene-1,2'-[5,7]ethenocyclobuta[i][1,4]oxazepino[3,4-f][1]thia[2,7]diazacyclohexadecin]-8'(9'H)-one 10',10'-dioxide
CBNumber: CB83339848
Molecular Formula: C33H41ClN2O5S
Formula Weight: 613.21
MOL File: 1883727-34-1.mol

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AMG176 Property

Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 4.05±0.70(Predicted)
color: White to off-white
InChIKey: JQNINBDKGLWYMU-GEAQBIRJSA-N
SMILES: S1(=O)(=O)[C@H](C)[C@@H](C)CC=C[C@H](OC)[C@]2([H])CC[C@@]2([H])CN2C[C@]3(C4=C(C=C(Cl)C=C4)CCC3)COC3C=CC(=CC2=3)C(=O)N1 |t:8|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb572995
Product name: AMG-176
Purity: >98%
Packaging: 100mg
Price: $1431.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb572995
Product name: AMG-176
Purity: >98%
Packaging: 250mg
Price: $2839
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb572995
Product name: AMG-176
Purity: >98%
Packaging: 1g
Price: $5654.2
Updated: 2021/12/16

DC Chemicals

Product number: DC12350
Product name: AMG-176
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC12350
Product name: AMG-176
Purity: >98%
Packaging: 1g
Price: $3800
Updated: 2021/12/16

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AMG176 Chemical Properties,Usage,Production

Uses

Tapotoclax (AMG-176) is a potent, selective and orally active MCL-1 inhibitor, with a Ki of 0.13 nM[1][2].

IC 50

Mcl-1: 0.13 nM (Ki)

References

[1] Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. DOI:10.1158/2159-8290.CD-18-0387
[2] Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142. DOI:10.1016/j.cbpa.2017.06.014

AMG176 Preparation Products And Raw materials

Raw materials

Preparation Products

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1883727-34-1, AMG176Related Search:

AMG176

CS-2836

Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-, 10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-

Tapotoclax

Tapotoclax（ AMG-176）

AMG-176 (TAPOTOCLAX)

(1S,11'R,12'S,16'S,16a'R,18a'R,E)-6-Chloro-16'-methoxy-11',12'-dimethyl-3,4,12',13',16',16a',17',18',18a',19'-decahydro-1'H,2H,3'H,11'H-spiro[naphthalene-1,2'-[5,7]ethenocyclobuta[i][1,4]oxazepino[3,4-f][1]thia[2,7]diazacyclohexadecin]-8'(9'H)-one 10',10'-dioxide

1883727-34-1

C33H41ClN2O5S